慢性阻塞性肺疾病患者急性加重期细胞因子的变化及沙美特罗替卡松的治疗效果

目的探讨慢性阻塞性肺疾病患者急性加重期（AECOPD）细胞因子的变化及沙美特罗替卡松的临床疗效。方法选择210例COPD患者做为研究对象,其中AECOPD患者120例,稳定期COPD患者90例。将120例AE-COPD患者随机分入对照组与观察组,每组各60例。对照组患者给予硫酸沙丁胺醇雾化吸入,观察组患者接受沙美特罗替卡松吸入治疗。结果 AECOPD患者血清细胞因子超敏C-反应蛋白（hs-CRP）、白介素8（IL-8）、肿瘤坏死因子-α（TNF-α）水平显著高于稳定期COPD患者（P〈0.01）;肺功能第1秒用力呼气容积（FEV1）,FEV1与用力肺活量比值（FEV1/FVC）显著低于稳定期COPD患者（P〈0.01）;治疗后观察组与对照组患者hs-CRP、IL-8、TNF-α均显著下降（P〈0.05）,但观察组患者细胞因子水平明显低于对照组（P〈0.05）,肺功能FEV1、FEV1/FVC值优于对照组（P〈0.05）。结论AECOPD血清细胞因子水平显著增高,沙美特罗替卡松可显著降低细胞因子水平,改善肺功能。

Cytokines change of acute exacerbation of chronic obstructive pulmonary disease and the clinical effect of Salmeterol and Fluticasone

Objective To explore the change of cytokines in acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and the clinical effect of Salmeterol and Fluticasone.Methods 210 cases of COPD were selected as research subjects,including 120 patients of AECOPD and 90 cases of stable COPD.120 cases of AECOPD were randomly divided into control group and experience group,each group had 60 cases.Control group were given Salbutamol by nebulization,and experience group received inhalation of Salmeterol and Fluticasone.Results hs-CRP,IL-8 and TNF-α in AECOPD patients were significantly higher than that in stable COPD patients(P < 0.01);FEV1 and FEV1/FVC were greatly decreased in AECOPD patients(P < 0.01);The level of hs-CRP、IL-8、TNF-αwere all decreased in experience group and control group after treatment(P < 0.05);But the cytokines level of experience group was much lower than that of control group,and FEV1,FEV1/FVC was superior to control group(P < 0.05).Conclusion Cytokines level is significantly increased in AECOPD patients.Salmeterol and Fluticasone can greatly decrease the cytokines level and improve lung function.