红葱的化学成分研究

目的研究红葱Eleutherine americana的化学成分。方法采用硅胶柱色谱、Sephadex LH-20柱色谱及重结晶等方法,分离纯化红葱的化学成分,通过MS、NMR等波谱技术确定化合物结构。结果确定了7个化合物的结构,分别为9-hydroxy-8-methoxy-1-methyl-1,3-dihydronaphtho[2,3-c]furan-4-O-β-D-glucopyranoside(1)、eleutherinoside A(2)、豆甾醇-3-O-β-D-葡萄糖苷(3)、kadsuric acid(4)、豆甾醇(5)、1,2-二羟基-8-甲氧基-3-甲基蒽醌(6)、9-methoxy-1,3-dimethyl-1H-naphtho[2,3-c]pyran-5,10-dione(7)。结论化合物1为新化合物,命名为红葱新苷。化合物3～5为首次从该植物中分离得到,化合物6和7为首次获得的新天然产物。

Chemical constituents of Eleutherine americana

Objective To investigate the chemical constituents from Eleutherine americana.Methods The chemical constituents were isolated and purified by column chromatography on silica gel,Sephadex LH-20,and recrystallization.Their structures were elucidated by means of MS and NMR.Results Seven compounds were isolated and identified as 9-hydroxy-8-methoxy-1-methyl-1,3-dihydronaphtho [2,3-c] furan-4-O-β-D-glucopyranoside(1),eleutherinoside A(2),stigmasterol-3-O-β-D-glucopyranoside(3),kadsuric acid(4),stigmasterol(5),1,2-dihydroxy-8-methoxy-3-methyl-anthra-9,10-quinone(6),and 9-methoxy-1,3-dimethyl-1H-naphtho [2,3-c] pyran-5,10-dione(7).Conclusion Compound 1 is a new glucopyranoside named eleuthamoside;compounds 3—5 are isolated from the plant for the first time,and compounds 6 and 7 are two new natural constituents.