强化他汀治疗对急性冠脉综合征患者PCI术后心肌灌注及炎症因子的影响

目的探讨强化他汀治疗对急性冠脉综合征（ACS）患者经皮冠状动脉介入治疗（PCI）术后心肌灌注及炎症因子的影响。方法将120例ACS行PCI治疗的患者随机分为对照组与观察组,给予58例对照组患者PCI术前1周20 mg/d阿托伐他汀口服,62例观察组患者于PCI术前1周开始口服40 mg/d阿托伐他汀。比较两组服药前及PCI术后血清炎症因子、心肌灌注分级（TMPG）和不良反应。结果 PCI术后12 h两组血清超敏C反应蛋白（hs-CRP）、IL-6及IL-8水平均显著升高,但观察组上述炎症因子水平显著低于对照组（P〈0.01）;术后观察组心肌灌注分级（TMPG）Ⅱ、Ⅲ级比例显著高于对照组（P〈0.01）;观察组与对照组不良反应发生率分别为21.0%和19.0%,差异无统计学意义（P〉0.05）。结论强化他汀治疗可显著降低ACS患者PCI术后急性炎症反应,显著改善心肌灌注,且不增加不良反应。

Effect of aggressive statin treatment on myocardial perfusion and inflammatory factors in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Objective To explore the effect of aggressive statin treatment on myocardial perfusion and inflammatory factors in patients with acute coronary syndrome(ACS) undergoing percutaneous coronary intervention(PCI).Methods 120 ACS patients undergoing undergoing elective PCI were randomly divided into control group and experience group.58 cases of control group were given oral administration of Atorvastatin(20 mg/d) 1 week before PCI,and 62 subjects of experience group received Atorvastatin(40 mg/d) treatment.Serum imflammatory factors,myocardial perfusion grading(TMPG) pre and post treatment and adverse reaction were compared between two groups.Results Serum hs-CRP,IL-6 and IL-8 were significantly increased in two groups 12 hours after PCI,but the level of inflammatory factors were much lower in experience group(P < 0.01);the patients of TMPG Ⅱ and Ⅲ in experience group were more than control group with significant difference(P < 0.01);the occurrence of adverse reaction were 21.0% and 19.0% respectively in experience group(P > 0.05).Conclusion Aggressive statin treatment in ACS patients undergoing PCI can decrease the inflammatory factors level postoperative,improve the myocardial perfusion without any increase in side effects.