Hp、p53在胃癌和癌前病变中的表达及相关性研究

目的:探讨Hp、p53在胃癌及癌前病变中的表达及相互关系.方法:采用特殊染色方法和免疫组化方法,检测130例不同胃粘膜病变石蜡包埋标本.结果:1.慢性浅表性胃炎(CSG)、慢性萎缩性胃炎(CAG)、非典型增生(DYS)和胃癌(GC)Hp阳性率分别为40%、60%、70%和72.5%,GC与CSG比较有显著差异(P<0.05).2.p53基因蛋白在CSG、 CAG、 DYS、 GC中的表达率分别为5%、 25%、 50%、 62.5%,其中GC与CAG、CSG 相比有明显差异(P<0.01).3.在80例胃癌标本中,Hp阳性组p53阳性表达率明显高于Hp阴性组(P<0.05). 结论: 1. Hp感染在胃粘膜病变的演变过程中起着重要作用. 2.突变型p53与胃癌的发生有关.3.p53的突变与Hp感染有密切关系.

STUDY ON THE EXPRESSION OF HP, P53 AND THEIR RELATIONSHIPS IN GASTRIC CANCER AND PRECANCEROUS LESIONS

Objective:To study the expression of Hp,p53 and their relationships in gastric cancer,precancerous lesions and their clinical signicance.Methods: Special staining and immunohischemistry were used in this study to detect 130 cases paraffin imbedding specimen of different gastric mucosal lesions.Results:1.The positive rate of Hp in GSG,CAG,DYS and GC were 40%,60%,70% and 72.5% respectively,and there were obvious difference between GC and CSG(P<0.05).2.The positive rate of p53 protein were 5%,25%,50% and 62.5% respectively in GSG,CAG,DYS and GC,and there were significant difference between GC and CAG,CSG(P<0.01).3.Among the 80 gastric cancers,the p53 positive rate in Hp positive group was much higher than in negative one(P<0.05).Conclusions: 1.Hp infection may play an important role in the development of gastric mucosal lesion.2.Mutable p53 is concerned with gastric cancer.3.The mutation of p53 gene has close relations to Hp infection.