急性脑梗死患者活化血小板的检测及临床价值

目的通过检测急性脑梗死患者血小板膜糖蛋白（CD62p）及血小板激活复合物（PAC-1）,探讨脑梗死患者血小板活化的临床意义。方法采用流式细胞仪测定45例急性脑梗死患者在发病48 h、6～8 d、3周时及35名正常对照者的血浆CD62p及PAC-1阳性百分率。结果脑梗死患者48 h内血浆CD62p（25.1%±7.4%）和PAC-1（65.2%±9.9%）阳性率明显高于正常对照组（4.0%±1.3%;8.2%±2.2%）（P〈0.01）。此后至3周逐渐下降,但仍高于正常对照组（P〈0.01）。结论急性脑梗死患者血小板处于高度活化状态,监测血小板活化程度对病情轻重的预测及指导临床用药有重要价值。

Clinical significance and detection of activated platelet in patients with acute cerebral infarction

Objective To investigate the clinical significance of activated platelet by detecting platelet membrane glycoprotein（CD62p） and platelet activation complex-1（PAC-1） in patients with acute cerebral infarction.Methods Flow cytometry was used to measure the positive percentages of CD62p and PAC-1 in 45 patients with acute cerebral infarction and 35 healthy subjects as control group.The measurement was carried out at the points of 48 h,6-8 d and 3 weeks after acute cerebral infarction＇s occurrence.Results In the patients with acute cerebral infarction within 48 h,the positive percentages of CD62p（25.1%±7.4%） and PAC-1（65.2%±9.9%） were higher than those in the control group（4.0%±1.3% and 8.2%±2.2%）（P0.01）.Then the levels decreased gradually within 3 weeks,but they still had higher values than those in control group（P0.01）.Conclusions The platelet of patients with acute cerebral infarction shows the highly activated state.It is important to monitor the platelet activation degree for predicting the clinical condition and guiding treatment.