生化检测指标在急性胰腺炎诊断中的临床意义

目的 探讨血淀粉酶(S-Amy)、尿淀粉酶(U-Amy)、胰脂肪酶(LPS)、胰蛋白酶原激活肽(TAP)和C反应蛋白(CRP)等5项生化指标在急性胰腺炎(AP)早期诊断和病情评估中的应用价值.方法 将265例急腹症患者分为AP组和非AP组,其中AP组根据病情严重程度分为轻症AP(MAP)和重症AP(SAP),同时选取3...

Clinical signfcance of biochemical indicator in diagnosis of acute pancreatitis

Objective To investigate the application significance of serum amylase（S-Amy）,urinary amylase（U-Amy）,lipase（LPS）,trypsinogen activation peptides（TAP） and C reactive protein（CRP） in diagnosing acute pancreatitis（AP） and assessing the severity of AP in the early stages.Methods 265 patients with acute abdomen were classified into AP and non-AP groups.AP patients were classified into mild AP group（MAP） and severe AP group（SAP）,and 35 healthy subjects were enrolled as control group.The 5 indicators were detected in these different groups.S-Amy,U-Amy and LPS were determined by rate method,TAP by double antibody sandwich enzyme-linked immunosorbent assay（ELISA） and CRP by particle enhanced nephelometry.Results The concentrations of S-Amy,U-Amy and TAP from high to low were AP groupnon-AP groupcontrol group with statistical significance（P0.01）.The concentration of LPS was higher in AP group than non-AP group（P0.01）.The concentrations of CRP in AP and non-AP groups were higher than that in the control group（P0.01）.The concentrations of U-Amy,TAP and CRP in SAP group were significantly higher than those in MAP group（P0.01）.However,the concentrations of S-Amy and LPS had no difference between SAP group and MAP group（P0.05）.In the diagnosis of early stage AP,the sensitivity and specificity were 92.1% and 91.6% in LPS,and were significantly higher than those in S-Amy,U-Amy,TAP and CRP.Conclusions The measurement of LPS may contribute to the early diagnosis of AP,while TAP and CRP can be used as early predictive indicators of changes in AP,as well as the treatment effect and severity of AP.