| 乳腺癌联合化疗患者凝血功能检测临床意义的探讨 |
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| 引用本文： | 张文芳,高云,郭鹏,王爱武,周美娟. 乳腺癌联合化疗患者凝血功能检测临床意义的探讨[J]. 中华肿瘤防治杂志, 2011, 18(6): 468-469,471 |
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| 作者姓名： | 张文芳 高云 郭鹏 王爱武 周美娟 |
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| 作者单位： | 河北省廊坊市人民医院肿瘤科,河北,廊坊,065000 |
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| 摘 要： | 为了探讨乳腺癌患者化疗时凝血参数的动态变化及临床意义,检测100例乳腺癌经手术患者化疗前后的凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、纤维蛋白原含量(FIB)、凝血酶时间(TT),并与100例健康体检者和良性肿瘤患者进行对比分析。观察患者化疗前后凝血指标的变化,比较组间和组内的差异。乳腺癌患者化疗前与对照组比较,PT、APTT和TT差异均无统计学意义(P>0.05),而FIB含量明显高于对照组,P<0.05。乳腺癌患者在化疗过程中PT和APTT无明显变化,与化疗前比较差异无统计学意义,P>0.05;而FIB含量化疗后比化疗前逐渐升高,差异有统计学意义,P<0.05。TT化疗后与化疗前对比逐渐缩短,差异有统计学意义,P<0.05。乳腺癌患者凝血指标的定期监测可能是判断乳腺癌预后以及化疗后复发和转移的有价值指标。
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| 关 键 词： | 乳腺肿瘤/药物治疗 凝血功能 药物疗法,联合 |
Clinical significance of blood coagulation function in patients with breast cancer treated by chemotherapy |
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| ZHANG Wen-fang,GAO Yun,GUO Peng,WANGA Ai-wu,ZHOU Mei-juan. Clinical significance of blood coagulation function in patients with breast cancer treated by chemotherapy[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(6): 468-469,471 |
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| Authors: | ZHANG Wen-fang GAO Yun GUO Peng WANGA Ai-wu ZHOU Mei-juan |
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| Affiliation: | ZHANG Wen-fang,GAO Yun,GUO Peng,WANG Ai-wu,ZHOU Mei-juan Department of Oncology,Langfang Municipality People's Hospital,Langfang 065000,P.R.China |
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| Abstract: | The objective of this study was to investigate the dynamic changes and clinical significance of blood coagulation function pre and post chemotherapy in patients with breast cancer.Prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and thrombin time(TT) were measured in 100 breast cancer patients pre and post chemotherapy.In addition,the results were compared with those in 100 healthy and benign tumor subjects(control group).The variation of coagulation indexes was observed pre a... |
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| Keywords: | breast neoplasms/drug therapy blood coagulation function drug therapy combination |
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