髓过氧化物酶、高敏C反应蛋白等在冠心病严重程度评估中的应用

目的分析冠心病病变程度与髓过氧化物酶（MPO）、高敏C反应蛋白（hs-CRP）、纤维蛋白原（FG）水平及白细胞计数（WBC）、中性粒细胞（Neu）百分比（%）、单核细胞（Mon）百分比（%）之间的关系。方法测定60例不稳定心绞痛（UA）、60例稳定性心绞痛（SAP）和50例冠状动脉造影阴性对照者的血清MPO（酶联免疫吸附试验）、血清hs-CRP（胶乳增强免疫比浊法）及FG水平,同时检测WBC、Neu（%）、Mon（%）。比较各组间的差异。所有冠状动脉造影阳性患者随访半年,记录再次发生心血管事件（包括死亡、心肌梗死、心源性猝死、脑卒中）。分析MPO与再次发生心血管事件之间的关系。结果 UA组MPO水平为（43.74±8.78）pg/L,明显高于SAP组（30.13±11.43）pg/L];而WBC、Neu（%）、Mon（%）及FG、hs-CRP水平2组之间无差异。UA组MPO、FG、hs-CRP水平及WBC、Neu（%）、Mon（%）明显高于冠状动脉造影阴性对照组（P〈0.05）。高水平MPO（〉40.56 pg/L）的冠心病患者再次发生心血管事件几率较高。结论血清MPO水平与冠心病病变程度密切相关,而且在UA的病理生理机制中起着更重要的作用。随访显示高水平MPO的冠心病患者再次心血管事件发生率较高。

The application of the serum myeloperoxidase and hs-CRP in severity evaluation of coronary heart disease

Objective To evaluate the relationship between the severity of coronary heart disease with myeloperoxidase（MPO）,high sensitive C reactive protein（hs-CRP）,fibrinogen（FG）,white blood cell（WBC）,neutrophil（Neu）（%） and moncyte（Mon）（%）.Methods 170 patients who had been completed coronary angiography and clinical diagnose were enrolled in this study.They were classified into 3 groups,unstable angina（UA） group（n=60）,stable angina pectoris（SAP） group（n=60）and the control group（n=50）.The level of serum MPO was measured by enzyme-linked immunosorbent assay,and the level of serum hs-CRP was detected by latex enhanced immunoturbidimetric assay.The levels of WBC,Neu（%）,Mon（%） and FG were also detected.The differences among the groups were analyzed.All patients with positive follow-up coronary angiography 6 months were recorded of the recurrence of cardiovascular events（death,myocardial infarction,sudden cardiac death and stroke）.The relationship between cardiovascular events and MPO was analyzed.Results The levels of MPO in UA group was（43.74±8.78）pg/L,and were significantly higher than those in SAP group（30.13±11.43）pg/L].The levels of WBC,Neu（%） and Mon（%）,FG and hs-CRP in patients of UA group and the SAP group were not significantly different.The levels of MPO,FG,hs-CRP,WBC,Neu（%） and Mon（%） in UA group were significantly higher than those in the control group（P0.05）.The rate of subsequent cardiovascular events was higher in the patients with high level of MPO（40.56 pg/L）.Conclusions The MPO level is closed with the severity of coronary heart disease.The value of MPO is important in the pathophysiology of UA.The serum MPO level shows that the reccurrence rate of cardiovascular events is higher in the patients with high level of MPO.