补肾活血中药对大鼠慢性高眼压模型多焦视网膜电图的影响

目的：观察补肾活血中药对大鼠慢性高眼压（elevated intraocular pressure，EIOp）模型视功能损害的干预作用。方法：采用烙闭上巩膜静脉的方法诱导产生慢性EIOP大鼠模型，将52只SD大鼠随机分为补肾活血高、中、低剂量组、模型组、空白组。连续灌胃8周，于8周末进行多焦视网膜电图（mulfifocal electroretinogram，mfERG）检测。结果：通过对大鼠mfERG-阶函数核（first older kernel，FOK）的观察发现，补肾活血中药有助于总波及1、2、3、4环P1波反应密度、总波P1波峰潜时、2环及3环N1波反应密度，3环、4环N1波峰潜时的恢复。结论：补肾活血中药可以改善大鼠慢性EIOP模型的视功能，有助于mfERG反应密度和波峰潜时的恢复。

Influences of Traditional Chinese Medicine of BuShenHuoXue on the Multifocal Electroretinogram of A Rat Model of Chronic Intraocular Hypertension

Objective： To observe the effect of Traditional Chinese Medicine （TCM） of BnshenHuoXue on the rat model of chronic, moderately elevated intraocular pressure.Methods： By unilaterally cauterizing 3 episderal vessels, the rat model of chronic, moderately elevated intraocular pressure was gotten.52 rots were divided into 5 groups randomly： model control group, treatment groups iwth high, middle, low dosage of BuShenHuoXue of TCM, and normal control group.After given drugs or normal saline for 8 weeks, to observe the effection by muhifocal electroretinogram （mfERG） .Results： To observe the mfERG first order kernel （FOK）, Bnshen- HuoXne of TCM can improve P1 wave＇ s 1, 2, 3, 4 ring＇ s amplitude density, P1 wave＇ s peak time, N1 wave＇ s 2, 3ring＇ s amplitude density and N1 wave＇ s 2, 3 ring＇ s peak time.Conclusion： BuShenHuoXue of TCM can protect the visual function from elevating intraeeular prer, sure, by improving mfERG＇ s amplitude density and peak time.So the mfERG can be a sensitivity method to evaluate its efficacy.