A model for quantitative evaluation of embolic stroke therapy |
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| Authors: | J A Zivin U DeGirolami A Kochhar P D Lyden V Mazzarella C C Hemenway M E Henry |
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| Affiliation: | Neurology Service, Veterans Administration Medical Center, San Diego, CA. |
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| Abstract: | We developed a small animal embolic stroke model for pharmacological screening trials. Microspheres are injected into the carotid circulations and group embolus dose-response relationships are calculated. Emboli quantity is related to neurologic injury, and small changes in neurologic function are detectable. Rabbits tolerated twice as many microspheres when cyproheptadine-treated after embolization. This demonstrated both the sensitivity of the model and the value of serotonin antagonists in reducing neurological injury. |
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