| 苯乙酸钠调控人前列腺癌细胞凋亡的研究 |
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| 引用本文： | 叶炯贤,赵建军,吴雄辉,吴军. 苯乙酸钠调控人前列腺癌细胞凋亡的研究[J]. 中国实验诊断学, 2002, 6(4): 216-217 |
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| 作者姓名： | 叶炯贤 赵建军 吴雄辉 吴军 |
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| 作者单位： | 北京大学深圳医院,广东,深圳,513086 |
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| 基金项目： | 深圳市卫生局科研基金资助 (编号 :2 0 0 10 4-17) |
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| 摘 要： | 目的 为了观察苯乙酸钠 (NaPA)对人前列腺癌细胞株 (PC - 3)的分化诱导作用。方法 应用流式细胞术(FCM)、台盼蓝染色计数法和3 H -TdR掺入法观察NaPA对人前列腺癌细胞株的细胞周期动力学变化的影响。结果 苯乙酸钠对人前列腺癌细胞株的细胞呈剂量依赖性抑制 ,细胞周期的G0 /G1期升高 ,S期、G2 /M期相对下降 ,表明NaPA可抑制人前列腺癌细胞株增殖 ,主要是S期合成降低。结论 提示NaPA通过诱导前列腺癌细胞凋亡治疗前列腺癌具有可期待前景。
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| 关 键 词： | 苯乙酸钠 前列腺癌细胞 凋亡 |
| 文章编号： | 1007-4287(2002)04-0216-02 |
| 修稿时间： | 2001-11-20 |
The effects of NaPA for apoptosis of prostate carcinoma cell |
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| YE Jiong-xian,ZHAO Jian-jun,WU Xiong-hui,et al.. The effects of NaPA for apoptosis of prostate carcinoma cell[J]. Chinese Journal of Laboratory Diagnosis, 2002, 6(4): 216-217 |
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| Authors: | YE Jiong-xian ZHAO Jian-jun WU Xiong-hui et al. |
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| Abstract: | Objective To study the induced differentiation action of phenylacete Natrium(NaPA) on human prostate carcinoma cell stain (PC-3)in vitro.Methods The cell biological changes of prostate carcinoma cell strain (PC-3) were observed by flow cytomtry technique (FCM),trypan blue dyeing count method and 3H-TdR method.Rsults A dosage dependent inhibition to NaPA and the rising of the G1 stage and the relatively declining of the S stage are presented. Conclusion NaPA can inhibite growth of PC-3cell by inducing apoptosis of prostate carcinoma cell. |
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| Keywords: | NaPA prostate carcinoma cell(PC-3) apoptosis |
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