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血小板活化和内皮细胞损害对大肠癌影响的临床研究
引用本文:朱卫健,王玫玫,张爱华,李小亮,吴红,孙达春. 血小板活化和内皮细胞损害对大肠癌影响的临床研究[J]. 血栓与止血学, 2011, 17(2): 66-68,72
作者姓名:朱卫健  王玫玫  张爱华  李小亮  吴红  孙达春
作者单位:珠海市人民医院,暨南大学医学院第三附属医院,珠海,519000
摘    要:目的研究血小板活化和内皮细胞损害对大肠癌病情和预后的影响。方法采用放射免疫法和酶联免疫法测定55例大肠癌和40例正常人血浆血栓烷B2(TXB2)、11-去氢-血栓烷B2(DH-TXB2)、血小板α-颗粒膜蛋白(GMP-140)、血管性血友病因子(vWF)、凝血酶调节蛋白(TM)、血清纤维结合蛋白(FN)和环磷酸乌苷(cGMP)含量。结果 (1)大肠癌TXB2、DH-TXB2、GMP-140、vWF、TM和cGMP升高,FN下降。(2)大肠癌cGMP与TXB2、DH-TXB2、GMP-140、TM之间均呈正相关。(3)合并感染TXB2、DH-TXB2升高,FN下降;已转移FN下降,其余指标升高;手术后FN升高,其余指标下降。结论大肠癌患者存在血小板活化和内皮细胞损害,二者影响大肠癌的转移和预后。

关 键 词:血小板活化  内皮细胞损害  大肠癌

The Study on the Activation of Platelet and Injury of Endothelial Cell Effects on Colorectal Cancer
ZHU Wei-jian,WANG Mei-mei,ZHANG Ai-hua,LI Xiao-liang,WU Hong,SUN Da-chun. The Study on the Activation of Platelet and Injury of Endothelial Cell Effects on Colorectal Cancer[J]. Chinese Journal of Thrombosis and Hemostasis, 2011, 17(2): 66-68,72
Authors:ZHU Wei-jian  WANG Mei-mei  ZHANG Ai-hua  LI Xiao-liang  WU Hong  SUN Da-chun
Affiliation:ZHU Wei-jian,WANG Mei-mei,ZHANG Ai-hua,LI Xiao-liang,WU Hong,SUN Da-chun(Zhuhai People's Hospital,the Third Affiliated Hospital of Jinan University,Zhuhai,519000,China)
Abstract:Objective To study the effects of platelet activation and injury of endothelial cell on colorectal cancer patients and their prognoses.Methods Radio-immunity and ELISA were employed to detect the TXB2,DH-TXB2,GMP-140,vWF,TM,FN and cGMP level in 55 cases of colorectal cancer patients and 40 cases of normal,healthy control persons.Result(1)The levels of TXB2,DH-TXB2,GMP-140,vWF,TM(thrombomodulin) and cGMP increased,while FN(fibronectin) decreased in colorectal cancer.(2)cGMP was positively related to TXB2,DH-...
Keywords:Platelet activation  Endothelial cell injury  Colorectal Cancer  
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