| 血小板活化和内皮细胞损害对大肠癌影响的临床研究 |
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| 引用本文： | 朱卫健,王玫玫,张爱华,李小亮,吴红,孙达春. 血小板活化和内皮细胞损害对大肠癌影响的临床研究[J]. 血栓与止血学, 2011, 17(2): 66-68,72 |
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| 作者姓名： | 朱卫健 王玫玫 张爱华 李小亮 吴红 孙达春 |
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| 作者单位： | 珠海市人民医院,暨南大学医学院第三附属医院,珠海,519000 |
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| 摘 要： | 目的研究血小板活化和内皮细胞损害对大肠癌病情和预后的影响。方法采用放射免疫法和酶联免疫法测定55例大肠癌和40例正常人血浆血栓烷B2（TXB2）、11-去氢-血栓烷B2（DH-TXB2）、血小板α-颗粒膜蛋白（GMP-140）、血管性血友病因子（vWF）、凝血酶调节蛋白（TM）、血清纤维结合蛋白（FN）和环磷酸乌苷（cGMP）含量。结果 （1）大肠癌TXB2、DH-TXB2、GMP-140、vWF、TM和cGMP升高,FN下降。（2）大肠癌cGMP与TXB2、DH-TXB2、GMP-140、TM之间均呈正相关。（3）合并感染TXB2、DH-TXB2升高,FN下降;已转移FN下降,其余指标升高;手术后FN升高,其余指标下降。结论大肠癌患者存在血小板活化和内皮细胞损害,二者影响大肠癌的转移和预后。
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| 关 键 词： | 血小板活化 内皮细胞损害 大肠癌 |
The Study on the Activation of Platelet and Injury of Endothelial Cell Effects on Colorectal Cancer |
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| ZHU Wei-jian,WANG Mei-mei,ZHANG Ai-hua,LI Xiao-liang,WU Hong,SUN Da-chun. The Study on the Activation of Platelet and Injury of Endothelial Cell Effects on Colorectal Cancer[J]. Chinese Journal of Thrombosis and Hemostasis, 2011, 17(2): 66-68,72 |
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| Authors: | ZHU Wei-jian WANG Mei-mei ZHANG Ai-hua LI Xiao-liang WU Hong SUN Da-chun |
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| Affiliation: | ZHU Wei-jian,WANG Mei-mei,ZHANG Ai-hua,LI Xiao-liang,WU Hong,SUN Da-chun(Zhuhai People's Hospital,the Third Affiliated Hospital of Jinan University,Zhuhai,519000,China) |
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| Abstract: | Objective To study the effects of platelet activation and injury of endothelial cell on colorectal cancer patients and their prognoses.Methods Radio-immunity and ELISA were employed to detect the TXB2,DH-TXB2,GMP-140,vWF,TM,FN and cGMP level in 55 cases of colorectal cancer patients and 40 cases of normal,healthy control persons.Result(1)The levels of TXB2,DH-TXB2,GMP-140,vWF,TM(thrombomodulin) and cGMP increased,while FN(fibronectin) decreased in colorectal cancer.(2)cGMP was positively related to TXB2,DH-... |
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| Keywords: | Platelet activation Endothelial cell injury Colorectal Cancer |
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