Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2

Authors:	Jonas?Cicenas Patrick?Urban Vincent?Vuaroqueaux Martin?Labuhn Willy?Küng Edward?Wight Mark?Mayhew Urs?Eppenberger Email author" target="_blank">Serenella?Eppenberger-Castori Email author

Institution:	(1) Stiftung Tumorbank Basel, Basel, Switzerland;(2) Department of Research, University Clinics,Molecular Tumor Biology, Basel, Switzerland;(3) OncoScore AG, Riehen, Switzerland;(4) Department of Gynecology, University Clinics, Basel, Switzerland;(5) Department of Anatomy and Cell Biology, University of Virginia, East Carolina School of Medicine, Charlottesville, Virginia, USA

Abstract:	Introduction Akt1, Akt2 and Akt3 kinases are downstream components of phosphoinositol 3-kinase derived signals from receptor tyrosine kinases, which influence cell growth, proliferation and survival. Akt2 overexpression and amplification have been described in breast, ovarian and pancreatic cancers. The present study was designed to investigate the prognostic significance of activated Akt in primary breast cancer and its association with other tumour biomarkers.

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