肿瘤细胞减灭术后行腹腔热灌注5-FU+卡铂化疗联合静脉化疗治疗晚期卵巢癌的效果观察#br#

目的探讨吉西他滨新辅助化疗(NACT)对比同步放化疗(CCRT)对年轻宫颈癌患者临床预后及细胞增殖-凋亡相关因子表达的影响。方法纳入局部晚期宫颈癌患者140例,随机分为观察组与对照组各70例。对照组采用吉西他滨和顺铂方案NACT,观察组采用以吉西他滨为基础CCRT。对比两组手术情况、副作用及生存情况,治疗前后血管内皮生长因子(VEGF)、Caspase-3、Survivin、Bax、Bcl-2表达。结果两组手术时间比较,差异无统计学意义(P0.05);观察组的手术时间及切缘阳性率均低于对照组(P 0.05)。观察组3年生存率显著高于对照组(P 0.05),观察组的复发、转移率显著低于对照组(P 0.05)。观察组放射性肠炎及放射性膀胱炎显著高于对照组(P 0.05)。治疗后,观察组的VEGF、Survivin、Bal-2阳性表达率、未复发转移低于对照组,Caspase-3、Bax阳性表达率、未复发转移患者高于对照组(P 0.05)。结论吉西他滨NACT与CCRT治疗年轻宫颈癌的近期疗效相当,但CCRT可能改善远期生存获益,其机制可能与抑制细胞增殖因子及上调细胞凋亡因子有关。

Clinical prognosis of neoadjuvant chemotherapy and concurrent chemoradiotherapy with gemcitabine for young patients with cervical cancer and influence on the expression of cell proliferation-apoptosis related factors

Objective?To study the effect of intraperitoneal hot perfusion of 5-FU and carboplatin chemotherapy combined with intravenous chemotherapy on advanced ovarian cancer after tumor cell reduction. Methods?A total of 98 patients with advanced ovarian cancer in the General Hospital of Pingmei Shenma Medical Group in Henan Province were selected and randomly divided into two groups. Results?Compared with the control group, the objective remission rate in the study group was significantly higher (P<0.05). Postoperative fever and anal exhaust time, cardiovascular system toxicity and renal function damage were observed in the two groups (P＞0.05). The patients with abdominal distension, bone marrow suppression, liver function damage, and gastrointestinal reactions in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusions?Intraperitoneal hyperthermic perfusion of 5-FU and carboplatin chemotherapy combined with intravenous chemotherapy after tumor cell reduction can effectively improve the clinical efficacy of advanced ovarian cancer, significantly reduce the occurrence of adverse reactions and improve the quality of life of patients. It has high effectiveness and good safety, and is worthy of clinical application.