艾滋病毒感染患者口腔黏膜疣状肿块人类乳头状瘤病毒感染的分型研究

目的探讨艾滋病毒感染患者口腔戮膜疵状肿块人类乳头状瘤病毒(1-IPV)感染及感染类型。方法应用 HPV Ll区通用引物Gp5十//G p6+和1-IPV特型引物(HPV6/II,16,18,31,33)，通过聚合酶链反应(PCR)，对34例艾滋病毒感染患者口腔豁膜沈状肿块人类乳头状瘤病毒(HPV) DNA进行检测。结果艾滋病毒感染患者口腔豁膜优状肿块中，HPV感染率为88.2%;亚型HPV6/II感染率为47.06%, HPV16感染率为II.76%, 1U〕V 18感染率为 2.94 % , HPV31感染率为5.88%。结论艾滋病毒感染患者口腔庆状肿块和H PV感染关系密切，而且大多数和低危型HPV6/II感染有关，少数病例和高危型HPV16,18,31感染有关;同一病例可以感染两种以上HPV亚型。

Typing Human Papilloma Virus( HPV) Infection in the Warts of Oral Mucosa from HIV-positive Patients

Objective To detect and type human papilloma virus (HPV) in the warts of oral mucosa from HIV-positive patients, and better understand the biological characters of these oral warts. Methods Polymerase chain reaction (PCR) was used to detect and type HPV infection by consensus HPV primers Gp5 + /Gp6 + and specific HPV primers (HPV6/11, 16, 18, 31, 33) in 34 cases of oral mucosa warts from HIV-positive patients. Results The HPV infection rate was 88.2% by consensus HPV primers Gp5 +/Gp6 + ; the HPV infection rate of HPV6/11, 16, 18, 31 was respectively 47.06%, 11.67%; 2.94%, and 5.88% by specific HPV primers. Conclusion Most lesions of oral warts from HIV-positive patients are associated with the infection of HPV. The low risk HPV6/11 infection is more common than the high risk HPV16, 18, 31.