| 水溶性药物骨架片释放达零级的几种方法 |
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| 引用本文： | 林晓,陈济民. 水溶性药物骨架片释放达零级的几种方法[J]. 中国药学杂志, 2002, 37(3): 192-195 |
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| 作者姓名： | 林晓 陈济民 |
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| 作者单位： | 1. 上海中医药大学中药学院药剂教研室,上海,200032
2. 沈阳药科大学药学系,辽宁,沈阳,110015 |
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| 摘 要： | 目的 研究水溶性药物骨架片释放达零级的方法。方法 以盐酸氢吗啡酮（hydromorphone hydrochloride）为模型药物，用熔融制粒法制备骨架片，用HPLC测定骨架片的释放度。结果 通过压制多层片和混合使用骨架材料，可解决盐酸氢吗啡酮骨架片前期释放偏快的问题，使整个释放近零级。结论 通过处方和工艺调整可以获得具有零级释放特征的水溶性药物骨架片。
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| 关 键 词： | 羟丙基甲基纤维素 羟甲基纤维素钠 十八醇 混合骨架片 盐酸氢吗啡酮 水溶性药物 释放速度 零有 |
| 文章编号： | 1001-2494(2002)03-0192-04 |
| 修稿时间： | 2001-02-16 |
Several approaches to prepare matrice containing soluble drug with zero-order release kinetics |
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| LIN Xiao ,CHEN Ji min. Several approaches to prepare matrice containing soluble drug with zero-order release kinetics[J]. Chinese Pharmaceutical Journal, 2002, 37(3): 192-195 |
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| Authors: | LIN Xiao CHEN Ji min |
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| Affiliation: | LIN Xiao 1,CHEN Ji min 2 |
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| Abstract: | OBJECTIVE To study methods to prepare matrice containing soluble drug with zero order release kinetics.METHODS The hydromorphone hydrochloride matrice was produced by melt granulation.The concentrations during the dissolution was determined by HPLC.RESULTS Through controlling the release area of matrice at the beginning of dissolution,incerasing the hydrophobicity of the matrix surface or shortenning the time to form the diffusion retarded layer on the matrix surface,zero order release of soluble drug was attained.CONCLUSION Through adjusting the formulation and preparation process,the matrice containing soluble drug,whose release behavior fited with zero order kinetics,can be made. |
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| Keywords: | HPMC CMC Na octadecanol combined matrix hydromorphone hydrochloride |
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