| 脑胶质瘤患者血清miR-21、miR-221、miR-222和miR-10b的相对表达量及临床意义 |
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| 引用本文： | 朱建军,李春生. 脑胶质瘤患者血清miR-21、miR-221、miR-222和miR-10b的相对表达量及临床意义[J]. 标记免疫分析与临床, 2015, 22(6): 511-513. DOI: 10.11748/bjmy.issn.1006-1703.2015.06.011 |
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| 作者姓名： | 朱建军 李春生 |
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| 作者单位： | 秦皇岛市青龙满族自治县医院脑外科,河北秦皇岛,066500;秦皇岛市青龙满族自治县医院脑外科,河北秦皇岛,066500 |
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| 摘 要： | 目的 探讨血清中miR-21、miR-221、miR-222和miR-10b对脑胶质瘤恶性程度的鉴别价值.方法 采用Real-timePCR技术检测34例低级别脑胶质瘤患者和50例高级别脑胶质瘤患者miR-21、miR-221、miR-222和miR-10b的相对表达量,使用受试者工作特征曲线(receiver operating characteristic curve,ROC)评价其诊断价值.结果 与低级别脑胶质瘤组相比,高级别脑胶质瘤组血清miR-10b、miR-21和miR-221的相对表达量均显著升高,且差异具有统计学意义,miR-222相对表达量的差异无统计学意义.ROC曲线评价血清miR-10b、miR-21和miR-221对于脑胶质瘤恶性程度的诊断价值,miR-10b的曲线下面积(area under curve,AUC)值最大,为0.722(0.694,0.751),对于低级别脑胶质瘤的诊断敏感性和特异性分别为79.41％和78.00％.使用二元Logistic回归分析评价血清miR-10b、miR-21和miR-221联合检测对于脑胶质瘤恶性程度的诊断价值,其曲线下面积为0.915(0.855,0.977),对于低级别脑胶质瘤的诊断敏感性和特异性分别为85.29％和88.00％.与miR-10b、miR-21和miR-221单独检测的诊断价值相比,其曲线下面积均有显著提高(P=0.026、P=0.012、P=0.008).结论 miR-10b、miR-21和miR-221联合诊断可以为临床脑胶质瘤患者的鉴别诊断提供一种潜在的辅助诊断方法.
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| 关 键 词： | 脑胶质瘤 血清 微小RNA 受试者工作特征曲线 二元Logistic回归分析 |
The Relative Expression of Serum miR-21 ,miR-221 ,miR-222 and miR-10b in Patients with Glioma and Its Clinical Significance |
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| ZHU Jian-jun,LI Chun-sheng. The Relative Expression of Serum miR-21 ,miR-221 ,miR-222 and miR-10b in Patients with Glioma and Its Clinical Significance[J]. Labeled Immunoassays and Clinical Medicine, 2015, 22(6): 511-513. DOI: 10.11748/bjmy.issn.1006-1703.2015.06.011 |
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| Authors: | ZHU Jian-jun LI Chun-sheng |
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| Abstract: | |
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| Keywords: | Glioma Serum Micro RNAs Receiver operating characteristic curve Binary logistic regression analysis |
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