门静脉主干及脾静脉宽度与肝组织纤维化程度的关系研究

目的　了解门静脉主干和脾静脉宽度与肝组织纤维化程度的关系。方法　 151例住院患者在B超引导下行肝活检 ,肝组织按肝纤维化分级标准分为S0 ～S4 。B超测量门静脉主干和脾静脉宽度。结果　S1至S4组门静脉主干和脾静脉宽度分别是 :S1为 (11 89± 1 39)mm和 (5 78± 1 33)mm ,S2 为 (12 2 2± 1 19)mm和(6 2 5± 1 2 8)mm ,S3为 (12 4 3± 1 2 6 )mm和 (7 0 3± 1 54)mm ,S4 为 (13 0 7± 1 2 3)mm和 (8 0± 1 80 )mm。S4组和S1、S2 组之间门静脉主干宽度差异具有显著性 (P值均 <0 0 1) ,S3组和S1组之间 (P值 <0 0 1)脾静脉宽度有显著性差异。结论　随着纤维化的发展 ,门静脉主干及脾静脉逐渐扩张。动态观察门静脉主干及脾静脉宽度对了解患者肝纤维化和门脉高压程度有一定的临床意义

A Study on Relationship Between the Liver Fibrosis Degree and the Diameters of Total Portal Vein and Spleen Vein

Objective To study the relationship between liver fibrosis degreeand widths of portal vein(TPV) and spleen vein(SPV).Method Liver specimens from 151 patients with chronic viral hepatitis were divided into 4 groups from S1 to S4 according to the liver fibrosis degree.The diameters of TPV and SPV were measured by ultrasonic B.Results The diameters of TPV and SPV of groups S1,S2,S3 and S4 were (11.89±1.39)mm and (5.78±1.33)mm,(12.22±1.19)mm and (6.25±1.28)mm,(12.43±1.26)mm and (7.03±1.54)mm，(13.07±1.23)mm and (8.0±1.80)mm,respectively.The differences of diameter of TPV between group S4 and group S1,S2 were significant(all P＜0.01).The diameter of SPV of group S3 was significantly different from group S1.The diameters of TPV and SPV can dilate gradually with developing liver fibrosis degrees.Conclusions Dynamic observations on the widths of TPV and SPV have some significance to know degree of liver fibrosis and portal hypertension in patients with chronic viral hepatitis.