平阳霉素瘤内注射治疗口腔颌面部血管瘤、血管畸形的系统评价

目的 对平阳霉素瘤内注射治疗口腔颌面部、头颈部血管瘤和血管畸形的疗效和安全性进行客观公正的评价。方法 计算机及人工检索中文文献。将纳入文献报道的患者性别，年龄范围，血管瘤类型、部位、大小和治疗效果等进行合并，计算各种类型血管瘤的疗效。结果 纳入的31篇文献全部为l临床回顾性研究，非随机、非对照。平阳霉素对不同类型血管瘤的治愈率依次为：获得性血管瘤(1岁后发现的血管瘤，实际为血管畸形)100％，海绵状血管瘤72．6％。混合型血管瘤65．0％，毛细血管瘤64．6％(草莓状血管瘤66．0％)，脉管瘤60％。纤维性血管瘤21．4％。葡萄酒色斑4．8％．对蔓状血管瘤无效。平阳霉素的疗效优于鱼肝油酸钠。结论 目前资料显示，平阳霉素瘤内注射治疗血管瘤和血管畸形有一定疗效。应根据血管瘤和血管畸形的最新分类。重新进行前瞻性随机对照试验。

Intralesional Injection of Pingyangmycin for Hemangiomas and Vascular Malformations in Oral and Maxillofacial Region: A Systematic Review of the Chinese Literature

Objective To assesses the efficac y and safety of intralesional injection of Pingyangmycin for hemangiomas and vascu lar malformations in head and neck including oral and maxillofacial region.Metho ds A systematic review of all relevant clinical trials in Chinese literature was performed using electric and hand searching.The reported sex,age ranges,the typ e,site,size of the tumors and the treatment results were identified and analyzed with conflation algorithm.Results All the included31articles were clinical retr ospective trials without random and control.The curative rates of Pingyangmycin were100%for acquired hemangioma,72.6%for cavernous hemangioma,65.0%for mixed hem angioma,64.6%for capillary hemangioma(66.0%for strawberry type),60%for vascular tumor,21.4%for fibrous hemangioma,4.8%for port wine stain,respectively.Pingyangm ycin had no effect on plexiform hemangioma.Conclusions Pingyangmycin is effectiv e for hemangioma and vascular malformations from the present data.Further random ized prospective controlled trials are needed using the new classification of Wa ner and Suen(1995)to draw reliable conclu-sions.