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Synthesis of tritiated Cyclosporin A and FK‐506 by metal‐catalyzed hydrogen isotope exchange |
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| Abstract: | Tritium‐labeled Cyclosporin A ( I ) and FK‐506 ( II ) have been prepared using a metal‐catalysed hydrogen isotope exchange procedure and high specific activity tritiated water. Specific activities of the labeled compounds were 0.15 and 0.59 TBq/mmol, respectively. Copyright © 2004 John Wiley & Sons, Ltd. |
| Keywords: | tritium labeling H/T‐exchange FK506 cyclosporin A |