左五合方对卵巢低反应者IVF/ICSI-ET助孕结局的影响

目的?评价左五合方对卵巢低反应（POR）者体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)卵巢反应性、妊娠相关指标的影响。方法?将100例肾精不足合脾气虚型POR患者随机分为治疗组和对照组各50例，2组均常规行IVF/ICSI-ET，其中治疗组以左五合方治疗3月再行IVF/ICSI-ET。比较2组患者促性腺激素（Gn）用量及用药天数、人绒毛膜促性腺激素（HCG）注射日雌二醇（E₂）及孕酮（P）水平、获卵数、优胚率、生化妊娠率、临床妊娠率、持续妊娠率。结果?2组Gn用量及用药天数、HCG日E₂和P水平、优胚率、生化妊娠率差异均无统计学意义（P>0.05）；治疗组获卵数、临床妊娠率、持续妊娠率均高于对照组（P<0.05）。结论?左五合方能提高POR者IVF/ICSI-ET的获卵数、临床妊娠率和持续妊娠率。 

Effect of Zuowu Decoction on the Outcome of Poor Ovarian Response Patients with IVF/ICSI-ET

OBJECTIVE?To evaluate the impact of Zuowu decoction on ovarian response and pregnancy related indicators of poor ovarian response (POR) patients with in vitro fertilization/ intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). METHODS?100 patients with POR due to deficiency of kidney-essence and spleen-qi were randomly divided into the treatment group and the control group with 50 cases in each. Both groups received routine IVF/ICSI-ET while the treatment group was pre-administrated with Zuowu Decoction for 3 months， and then given IVF/ICSI-ET. The dosage and administration duration of gonadotropin (Gn)， the levels of estradiol (E₂) and progesterone (P) on human chorionic gonadotropin(HCG) trigger day， number of retrieved oocytes， high-quality embryo rates， biochemical pregnancy rate， clinical pregnancy rate and ongoing pregnancy rate were compared between the two groups. RESULTS?The differences of the following indicators were no statistically significant: the dosage and administration duration of Gn， the level of E₂ and P on HCG trigger day， high-quality embryo rates and biochemical pregnancy rate (P>0.05). The number of retrieved oocytes， clinical pregnancy rate and ongoing pregnancy rate in the treatment group were all higher than those in the control group (P<0.05). CONCLUSION?Zuowu Decoction can increase the number of retrieved oocytes， clinical pregnancy rate and ongoing pregnancy rate in POR patients with IVF/ICSI-ET treatment.