首页 | 本学科首页   官方微博 | 高级检索  
     

低能量冲击波治疗勃起功能障碍疗效及安全性:随机对照试验的meta分析
引用本文:莫敦胜,詹绪新,石红卫,蔡鸿财,孟君,赵静,商学军. 低能量冲击波治疗勃起功能障碍疗效及安全性:随机对照试验的meta分析[J]. 中华男科学杂志, 2019, 0(3): 257-264
作者姓名:莫敦胜  詹绪新  石红卫  蔡鸿财  孟君  赵静  商学军
作者单位:广西医科大学第四附属医院/柳州市工人医院泌尿外科;西安市第四医院生殖医学科;西安市第四医院中医科;华中科技大学同济医学院计划生育研究所/生殖医学中心;德盛昌中医门诊部;南京大学医学院附属金陵医院男科;南方医科大学南京临床医学院/东部战区总医院男科
摘    要:目的:依据现有临床证据评价低能量冲击波(LI-ESWT)治疗勃起功能障碍(ED)的临床疗效及安全性。方法:通过计算机检索PubMed、Medline、EMBASE、Cochrane图书馆和CNKI、VIP、CBM、万方数据库建库至2018年6月有关LI-ESWT治疗ED的随机对照试验(RCT),由2名研究者按照纳入与排除标准进行文献筛选、资料提取和质量评价,并采用RevMan 5.3软件进行meta分析。结果:共纳入来自8项随机双盲对照研究的595例ED患者,其中LI-ESWT治疗组362例,对照组233例。meta分析结果显示,与对照组相比较,LI-ESWT治疗可显著提高ED患者的IIEF评分[WMD=1.70, 95%CI (0.44, 2.96),P=0.008]和勃起硬度分级(EHS)[RR=11.72, 95%CI (5.13, 26.80),P<0.01]。进一步分析表明LI-ESWT治疗后随访4周和24周ED患者的IIEF评分均显著提高[WMD=1.43, 95%CI (0.10, 2.75),P=0.03; WMD=3.09, 95%CI (1.49, 4.68),P=0.000 2];LI-ESWT治疗10~12次ED患者的IIEF评分显著提高,而治疗5~6次IIEF评分并未显示出明显增加[WMD=1.81, 95%CI (0.31, 3.31),P=0.02; WMD=1.88,95%CI (-2.10, 5.86),P=0.35];基线IIEF≥12分ED患者LI-ESWT治疗后IIEF评分明显增加而基线IIEF≤11分治疗后IIEF评分并未显示出明显增加[WMD=2.13, 95%CI (0.51, 3.75),P=0.01; WMD=1.04, 95%CI (-0.96, 3.03),P=0.31]。8项研究报告了LI-ESWT治疗后均无明显不良反应发生。结论:LI-ESWT作为一种非侵入性治疗手段,其可明显改善ED患者的IIEF评分和EHS分级,临床应用安全有效。

关 键 词:低能量冲击波  勃起功能障碍  国际勃起功能指数  勃起硬度分级  META分析

Efficacy and safety of low-intensity extracorporeal shock wave therapy in the treatment of ED: A meta-analysis of randomized controlled trials
MO Dun-sheng,ZHAN Xu-xin,SHI Hong-wei,CAI Hong-cai,MENG Jun,ZHAO Jing,SHANG Xue-jun. Efficacy and safety of low-intensity extracorporeal shock wave therapy in the treatment of ED: A meta-analysis of randomized controlled trials[J]. National journal of andrology, 2019, 0(3): 257-264
Authors:MO Dun-sheng  ZHAN Xu-xin  SHI Hong-wei  CAI Hong-cai  MENG Jun  ZHAO Jing  SHANG Xue-jun
Affiliation:(Department of Urology, Liuzhou Workers’ Hospital/The Fourth Affiliated Hospital of Guangxi Medical University,Linzhou, Guangxi 545005 , China;Department of Reproductive Medicine,Xi’an No.4 Hospital,Xi'an , Shaanxi 710004, China;Department of Traditional Chinese Medicine, Xi’an No.4 Hospital,Xi'an , Shaanxi 710004;Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, Hubei 430030, China;Deshengchang Clinic of Traditional Chinese Medicine, Xianyang, Shaanxi 712000, China;Department of Andrology, Jinling Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210002 , China;Department of Andrology, Nanjing School of Clinical Medicine, Southern Medical University / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002 , China)
Abstract:MO Dun-sheng;ZHAN Xu-xin;SHI Hong-wei;CAI Hong-cai;MENG Jun;ZHAO Jing;SHANG Xue-jun(Department of Urology, Liuzhou Workers’ Hospital/The Fourth Affiliated Hospital of Guangxi Medical University,Linzhou, Guangxi 545005 , China;Department of Reproductive Medicine,Xi’an No.4 Hospital,Xi'an , Shaanxi 710004, China;Department of Traditional Chinese Medicine, Xi’an No.4 Hospital,Xi'an , Shaanxi 710004;Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, Hubei 430030, China;Deshengchang Clinic of Traditional Chinese Medicine, Xianyang, Shaanxi 712000, China;Department of Andrology, Jinling Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210002 , China;Department of Andrology, Nanjing School of Clinical Medicine, Southern Medical University / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002 , China)
Keywords:low-intensity extracorporeal shock wave therapy  erectile dysfunction  International Index of Erectile Function index  erection hardness score  meta-analysis
本文献已被 CNKI 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号