益气活血化痰方对经皮冠状动脉介入术后慢血流患者的干预作用

目的?观察益气活血化痰方对经皮冠状动脉介入术（PCI）后慢血流患者冠状动脉血流和主要临床症状的改善作用。方法?将44例患者随机分为治疗组和对照组各22例。所有患者在术后24?h起每日给予常规冠心病二级预防药物（双重抗血小板药物、他汀类药物、ACEI/ARB类药物和β受体阻滞剂）治疗，治疗组在此治疗基础上加服益气活血化痰中药，每日1剂。治疗3月后，观察2组治疗前后的冠状动脉血流（TIMI血流分级和校正的TIMI帧数）变化，中医证候积分和主要临床症状(心绞痛发生次数、持续时间、硝酸甘油用量)的改善情况。结果?治疗组治疗后TIMI血流分级和校正的TIMI帧数有显著改变(P<0.05~0.01)；治疗组治疗前后中医证候积分显著降低(P<0.01)，主要临床症状显著改善(P<0.01)，改善程度明显优于对照组(P<0.05~0.01)。结论?益气活血化痰方可改善冠状动脉介入术后慢血流患者冠状动脉血流和主要临床症状。 

Effect of Yiqi Huoxue Huatan Recipe on Patients with Slow Blood Flow After Percutaneous Coronary Intervention

OBJECTIVE?To observe the effect of Yiqi Huoxue Huayu recipe on coronary blood flow and main clinical symptoms in patients with slow blood flow after percutaneous coronary intervention (PCI). METHODS?44 patients were randomly divided into treatment group and control group， 22 cases in each group. All patients received daily secondary prevention drugs for coronary heart disease (double antiplatelet drugs， statins， ACEI/ARB drugs and beta blockers) from 24 hours after surgery. On the basis of this treatment， The treatment group was given Yiqi Huoxue Huatan recipe， one dose a day. After 3 months of treatment， the changes of coronary blood flow (TIMI blood flow grading and corrected TIMI frame) before and after treatment， TCM syndrome scores and main clinical symptoms (number of angina pectoris， duration， nitroglycerin dosage) were observed. RESULTS?The TIMI blood flow grading and corrected TIMI frame number in the treatment group were significantly changed (P<0.05， P<0.01). The TCM syndrome scores in the treatment group were significantly lower before and after treatment (P<0.05， P<0.01). The main clinical symptoms were significantly improved (P<0.01)， the degree of improvement was significantly better than the control group (P<0.01). CONCLUSION?Yiqi Huoxue Huatan recipe can improve coronary blood flow and main clinical symptoms in patients with slow blood flow after PCI.