中药经皮给药脂质体的研究与展望

中药经皮给药有悠久的应用历史，脂质体作为新型载体用于中药活性成分的经皮给药可以提升药物在局部的皮内滞留或（和）透皮吸收效果，从而显著改善药效。该文从皮肤屏障的特点、中药经皮给药概况、脂质体促进经皮吸收的机制与影响因素、中药经皮给药脂质体的皮内滞留、中药经皮给药脂质体的透皮吸收等5个方面对相关研究进展进行了综述，涉及常规脂质体以及传递体、醇质体、萜质体、甘油体、表面修饰脂质体等新型脂质体的应用，并提出了坚持正确的研究方向、提升制剂技术水平和提高研究技术水平三方面的展望。 

Progress and Prospects on the Development of Liposomes for Dermal and Transdermal Delivery Application in the Field of Traditional Chinese Medicine

Percutaneous administration has been used for about 3000 years in the field of Traditional Chinese Medicine (TCM). As carriers， liposomes have been proved to improve the skin disposition and/or transdermal absorption effects of TCM active components following percutaneous delivery， resulting in the enhanced therapeutic efficacy. In the present paper， the properties of skin， the history and status of TCM percutaneous application， the mechanism and affecting factors of liposomes acting on skin， the skin disposition of liposomes containing TCM active components and transdermal absorption of liposomes containing TCM active components were intensively summarized and discussed. A lot of novel liposomes were also introduced， including transfersomes， ethosomes， invasomes， glycerosomes and surface-modified liposomes. The prospects about correct development direction， the enhancement of drug preparation technique and the improvement of research technique were also proposed.