| Abstract: | Ginkgolide B, a terpene trilactone constituent of Gingko biloba extracts and an antagonist for the platelet activating factor (PAF) receptor, was radiolabeled with the positron emitter 18F for visualizing its in vivo behavior using positron emission tomography (PET). The 7‐18F]fluoro analog of ginkgolide B (7‐18FGB) was synthesized via nucleophilic displacement of the triflate group at C7 with 18F]fluoride. The reaction was complete in 5–10 min, affording 7‐18FGB in an average radiochemical yield of approximately 16% (decay corrected). The average specific activity at E.O.S. was approximately 40 GBq/µmol, and the radiochemical and chemical purity was greater than 95%. Copyright © 2004 John Wiley & Sons, Ltd. |
