A rapid one‐step radiosynthesis of the β‐amyloid imaging radiotracer N‐methyl‐[11C]2‐(4′‐methylaminophenyl)‐6‐hydroxybenzothiazole ([11C]‐6‐OH‐BTA‐1)

The promising β‐amyloid PET imaging agent, ¹¹C]‐6‐OH‐BTA‐1, has been radiolabelled in one step using ¹¹C]‐methyl triflate. No protection of the 6‐hydroxy group is required, greatly simplifying the synthetic method. The reaction may be carried out in solution or by the captive solvent ‘loop’ method. Copyright © 2004 John Wiley & Sons, Ltd.