1，25-二羟维生素D3治疗糖尿病肾病疗效观察

目的:探讨1,25-二羟维生素D_3治疗糖尿病肾病(DN)的疗效。方法:将60例DN患者随机分为试验组和对照组,每组30例。2组患者均接受常规降糖治疗,对照组患者口服厄贝沙坦150～300 mg/d;试验组患者口服厄贝沙坦150～300 mg/d,联合口服阿法骨化醇0.25μg,1次/d。记录并比较2组患者治疗前、后血糖化血红蛋白、肌酐等水平。结果:治疗3个月后试验组肌酐、尿N-乙酰-β-氨基葡萄糖苷酶、尿蛋白、血转化生长因子β_1均显著低于对照组(均P0.05)。结论:1,25-二羟维生素D_3对DN患者有肾保护作用。

Effect of 1,25-dihydroxyvitamin D3 in the treatment of diabetic nephropathy

Objective To study the effects of 1,25- dihydroxyvitamin D3 in diabetic nephropathy (DN). Methods 60 patients with DN were selected from our hospital from 2013 Jan. to 2015 Sep., They were randomly divided into experimental group (EG, n=30) and control group (CG, n=30). All patients were given the routine hypoglycemic treatment. The control group was treated with irbesartan 150mg to 300mg/day; experimental group were treated with irbesartan 150mg to 300mg/day,combined with oral administration of alfacalcidol 0.25 ug, 1 times/day. The HbA1c, creatinine and other biochemical test results before and after the treatement of the patients were recoded. Results After treatment, the Scr, NAG, UPRO, blood TGF- beta 1 in the control group were significantly higher than those in the experimental group, and the difference was statistically significant (P<0.05) Conclusion 1,25-dihydroxyvitamin D3 Can protect the kidney function, reduce the damage of DN to the kidney, have clinical application value.