基于脾胃理论探讨脾气虚病机与细胞自噬功能紊乱的相关性

细胞自噬作为细胞的分解代谢过程,在维持机体生长、发育、免疫防御等功能上与中医脾胃的生理功能具有一定的相关性。基于中医脾胃理论,从机体运化失调、卫气不固及气血津液输布失常等脾气虚病机着手,同时结合现代医学对自噬功能下降在细胞代谢、免疫防御及衰老中的研究成果,分析脾气虚病机与自噬功能紊乱之间的关联,提出自噬功能下降可视为中医脾气虚的微观病机,为揭示脾气虚的微观本质提供思路。 

Correlation Between Spleen-Qi Deficiency Pathogenesis and Autophagy Dysfunction Based on Spleen and Stomach Theory

Cell autophagy, as a process of cell decomposition and metabolism, has a certain correlation with the physiological functions of spleen and stomach in traditional Chinese medicine (TCM) in maintaining the body's growth, development, immune defense and other functions. Based on the spleen and stomach theory, starting from the spleen-qi deficiency pathogenesis such as the body's transport disorder, insecurity of defense qi and the disorder of qi and blood supply and distribution, and combining with the research results of modern medicine on the decline of autophagy in cell metabolism, immune defense and aging, this paper analyzes the relationship between the spleen-qi deficiency pathogenesis and autophagy dysfunction, and puts forward that the decline of autophagy can be regarded as the microscopic pathogenesis of spleen-qi deficiency in TCM, and provides ideas for revealing the microscopic nature of spleen-qi deficiency.