Liguzinediol对阿霉素诱导的慢性心衰大鼠心功能的影响

目的 通过阿霉素（Dox）复制大鼠慢性心力衰竭（CHF）模型,观察Liguzinediol对CHF大鼠心功能的影响。方法 通过血流动力学观察Liguzinediol对Dox（腹腔注射,2 mg/kg）诱导的CHF大鼠左心室内压最大上升/下降速率(±dp/dt_max)、左心室内压(LVSP)、动脉收缩压(ASP)、动脉舒张压(ADP)和心率(HR)的变化;观察Liguzinediol对血清一氧化氮（NO）、一氧化氮合成酶（NOS）、超氧化物歧化酶（SOD）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）以及血浆中丙二醛（MDA）的影响。结果 Liguzinediol能增加LVSP、+dp/dt_max、ASP、ADP、AP、HR,降低-dp/dt_max(P<0.05~0.01);降低NO、iNOS以及MDA的浓度,同时增强了SOD的活性(P<0.05~0.01);抑制IL-6和TNF-α的生成(P<0.05~0.01)。结论 Liguzinediol可明显改善Dox诱导的CHF大鼠血流动力学指标,减少模型大鼠炎症因子的释放以及抑制氧自由基的生成。 

Effects of Liguzinediol on Hemodynamics in Chronic Heart Failure Rats Induced by Doxorubicin

OBJECTIVE To explore the effect of Liguzinediol on cardiac function, ventricular remodeling and inflammation in chronic heart failure (CHF) rat model induced by doxorubicin (Dox). METHODS The hemodynamic changes in the maximum ascending/descending rate of left ventricular pressure (+dp/dt_max), left ventricular pressure (LVSP), arterial systolic pressure (ASP), arterial diastolic pressure (ADP) and heart rate (HR) were recorded by multichannel physiological recorder with intragastric administration of Liguzinediol in CHF rats induced by Dox (intraperitoneal injection, 2 mg/kg). The effects of Liguzinediol on oxygen free radicals (NO, NOS, SOD, MDA) and inflammatory factors (IL-6 and TNF-α) were also detected by the kits. RESULTS Liguzinediol increased the levels of LVSP, +dp/dt_max, ASP, ADP, AP and HR, and decreased the level of -dp/dt_max(P<0.05,P<0.01). Liguzinediol decreased the concentration of NO, iNOS and MDA , increased the activity of SOD, and inhibited the contents of IL-6 and TNF-α(P<0.05,P<0.01). CONCLUSION Liguzinediol can improve ventricular remodeling by reducing the release of inflammatory factors, inhibiting the formation of oxygen free radicals.