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锯叶棕果实提取物对慢性前列腺炎大鼠生殖功能影响的实验研究
引用本文:詹绪新,莫敦胜,蔡鸿财,薛松,商学军.锯叶棕果实提取物对慢性前列腺炎大鼠生殖功能影响的实验研究[J].中华男科学杂志,2019(5):399-402.
作者姓名:詹绪新  莫敦胜  蔡鸿财  薛松  商学军
作者单位:西安市第四医院生殖医学科;广西医科大学第四附属医院/柳州市工人医院泌尿系外科;华中科技大学计划生育研究所/生殖医学中心;东部战区总医院泌尿外科;南方医科大学南京临床医学院/东部战区总医院男科
摘    要:目的:探讨锯叶棕果实提取物(SPE)对慢性前列腺炎(CP)模型大鼠生殖功能的影响。方法:40只雄性SD大鼠随机分为4组,每组10只。A组:空白对照组;B组:空白对照+SPE治疗组;C组:CP模型对照组;D组:CP模型+SPE治疗组。A、C组采用生理盐水灌胃,B、D组给予SPE0.10 g/(kg·d)]灌胃,连续30 d。对SD大鼠前列腺背侧叶注射λ-角叉菜胶建立慢性非细菌性CP模型,停药次日各组大鼠按1∶1比例与雌鼠做交配实验,1周后断颈处死所有雄鼠,取双侧附睾以检测大鼠精子活率及精子计数,同时记录雌鼠妊娠率及仔鼠数。结果:与A组相比,C组大鼠附睾尾精子活率显著降低(68.01±1.80)%vs(62.59±4.82)%,P<0.05]。B、D组大鼠附睾精子活率(67.69±4.06)%、(67.93±3.39)%]与A组比较无显著性差异(P>0.05);与A组相比,各组大鼠附睾尾精子计数、雌鼠妊娠率及胎仔数均无统计学差异(P>0.05)。结论:SPE可改善CP大鼠的精液参数,使雌鼠受孕后不影响雌鼠妊娠率及胎仔数。

关 键 词:锯叶棕果实提取物  慢性前列腺炎  生殖功能  精子活率  精子计数  大鼠

Effect of saw palmetto extract on the reproductive function of male rats with chronic prostatitis
ZHAN Xu-xin,MO Dun-sheng,CAI Hong-cai,XUE Song,SHANG Xue-jun.Effect of saw palmetto extract on the reproductive function of male rats with chronic prostatitis[J].National Journal of Andrology,2019(5):399-402.
Authors:ZHAN Xu-xin  MO Dun-sheng  CAI Hong-cai  XUE Song  SHANG Xue-jun
Institution:(Department of Reproductive Medicine,Xian No. 4 Hospital,Xian,Shaanxi 710004,China;Department of Urology,Liuzhou WorkersrHospital / The Fourth Affiliated Hospital of Guangxi Medical University,Liuzhou,Guangxi 545005,China;Family Planning Research Institute / Center of Reproductive Medicine,Huazhong University of Science and Technology,Wuhan Hubei 430030,China;Department of Urology,General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Andrology,Nanjing School of Clinical Medicine,Southern Medical University / General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)
Abstract:ZHAN Xu-xin;MO Dun-sheng;CAI Hong-cai;XUE Song;SHANG Xue-jun(Department of Reproductive Medicine,Xian No. 4 Hospital,Xian,Shaanxi 710004,China;Department of Urology,Liuzhou WorkersrHospital / The Fourth Affiliated Hospital of Guangxi Medical University,Liuzhou,Guangxi 545005,China;Family Planning Research Institute / Center of Reproductive Medicine,Huazhong University of Science and Technology,Wuhan Hubei 430030,China;Department of Urology,General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Andrology,Nanjing School of Clinical Medicine,Southern Medical University / General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)
Keywords:saw palmetto extract  chronic prostatitis  reproductive function  sperm motility  sperm count  rat
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