纤支镜下肺泡灌洗联合依替米星局部给药治疗支气管扩张并感染患者疗效观察

目的观察纤支镜下肺泡灌洗联合依替米星局部给药治疗支气管扩张并感染患者的临床效果。方法选取2016年7月至2018年6月我院收治的支气管扩张并感染患者160作为研究对象,随机分为对照组(75例)与观察组(85例)。在常规对症及抗感染治疗的基础上,对照组患者给予纤维支气管镜下肺泡灌洗治疗;观察组患者在对照组组治疗基础上,给予依替米星局部给药治疗。治疗2周,比较两组患者的疗效、临床表现、动脉血氧分压(PaO2)、血氧饱和度(SaO2)、动脉血二氧化碳分压(PaCO2)以及并发症发生率。结果观察组患者的治疗总有效率(95.3%)明显高于对照组(84.0%),差异有统计学意义(P<0.05)。观察组患者发热消退时间、咳嗽咳痰改善时间、肺部炎性病灶消失时间均显著短于对照组,差异有统计学意义(P<0.05)。治疗2周后,两组患者的PaO2、SaO2、PaCO2均显著改善,观察组患者的改善情况优于对照组,差异有统计学意义(P<0.05)。治疗期间两组患者的并发症发生率比较,差异无统计学意义(P>0.05)。结论纤维支气管镜下肺泡灌洗联合依替米星局部给药治疗支气管扩张并感染患者临床疗效显著,可显著改善临床症状及血气状况,治疗安全性高,值得推广应用。

Efficacy observation of bronchoalveolar lavage combined with topical administration of etimicin on patients with bronchiectasis and infection

Objective To observe the clinical efficacy of bronchoalveolar lavage combined with topical administration of etimicin on patients with bronchiectasis and infection.Methods A total of 160 patients with bronchiectasis and infection admitted to our hospital from July 2016 to June 2018 were selected and randomly divided into the control group (75 cases) and the observation group (85 cases).On the basis of conventional symptomatic and anti-infective treatment,the control group was treated with bronchoalveolar lavage,while the observation group was treated with topical administration of etimicin on the basis of treatment in the control group.After 2 weeks of treatment,the efficacy,clinical manifestation,arterial oxygen partial pressure (PaO2),oxygen saturation (SaO2),arterial carbon dioxide partial pressure (PaCO2) and complications incidence rate were compared between the two groups.Results The total effective rate of treatment in the observation group (95.3%) was significantly higher than that in the control group (84.0%),and the difference was statistically significant ( P <0.05).The time of fever subsidence,cough improvement and pulmonary inflammatory lesions disappearance in the observation group were significantly shorter than those in the control group,and the difference was statistically significant ( P <0.05).After 2 weeks of treatment,the PaO2,SaO2 and PaCO2 in both groups significantly improved;the improvement in the observation group was better than that in the control group,and the difference was statistically significant ( P <0.05).There was no statistically significant difference in complications incidence rate between the two groups during treatment ( P >0.05).Conclusion The clinical efficacy of bronchoalveolar lavage combined with topical administration of etimicin on patients with bronchiectasis and infection is prominent.It can significantly improve clinical symptoms and blood gas status;it has high safety and it is worthy of promotion and application.