| 热应激蛋白70抗体与高血压关系初探 |
| |
| 引用本文： | Ma J,Sun Y,Cao D,Chen S,Xiao C,Wu J,Wu T. 热应激蛋白70抗体与高血压关系初探[J]. 中华预防医学杂志, 2000, 34(1): 14-16 |
| |
| 作者姓名： | Ma J Sun Y Cao D Chen S Xiao C Wu J Wu T |
| |
| 作者单位： | 马金香（合肥市 安徽医科大学流行病学教研室 230032） |
| |
| 基金项目： | 安徽省教委自然科学基金!97j10 79 |
| |
| 摘 要： | 目的 探讨热应激蛋白７０（ＨＳＰ７０）抗体与高血压之间的关系。方法 用Ｗｅｓｔｅｒｎｂｌｏｔ免疫印迹法检测高血压且和非高血压组血清ＨＳＰ７０抗体水平。采用ｌｏｇｉｓｔｉｃ回归分析技术,分析ＨＳＰ７０抗体与高血压之间的关系。结果 在排除高公认的影响因素（年龄、性别、工龄、体块指数等）以及工种的影响后,高血压组清ＨＳＰ７０抗体水平明显高于对照组：以１４０／９０ｍｍＨｇ为标准,高血压与ＨＳＰ７０抗体仍存
|
| 关 键 词： | 高血压 热休克蛋白 抗体 HSP70 |
| 修稿时间： | 1999-08-24 |
Preliminary study on relationship between antibody against heat stress protein 70 and hypertension |
| |
| Ma J,Sun Y,Cao D,Chen S,Xiao C,Wu J,Wu T. Preliminary study on relationship between antibody against heat stress protein 70 and hypertension[J]. Chinese Journal of Preventive Medicine, 2000, 34(1): 14-16 |
| |
| Authors: | Ma J Sun Y Cao D Chen S Xiao C Wu J Wu T |
| |
| Affiliation: | Department of Epidemiology, Anhui Medical Univisity, Hefei, 230032, China. |
| |
| Abstract: | Objective Topreliminarilyexploretherelationshipbetweenmainantibodyagainstheatstress protein 70 (anti HSP70 )andhypertension .Methods Serumanti HSP70wasdeterminedwithWesternblotting techniqueinhypertensiveandnormotensivegroups .Logisticregressionmodelwasusedtoanalyzetherelationship betweenanti HSP70andhypertension .Results Itwasfoundthatlevelofantibodyagainstthemainheatshock protein 70wassignificantlyhigherinpatientswithhypertension (basedoncriteriaof160 95mmHg ,1mmHg = 0 13 3kPa)thanincontrols ,afteradjustmentforthegenerallyrecognizedriskfactorsforhypertension (suchas age ,sex ,lengthofemployment,bodymassindex ,job ,etal.) .Therestillwasstrongerassociationbetweenanti HSP70andhypertension (basedoncriteriaof14 0 90mmHg) ,butitsstrengthofassociationwasweakerthanthe former.Conclusions Anti HSP70maypotentiallyserveasaserumbiomarkertoassesshypertension ,oranti HSP70itselfmaybeinvolvedinthedevelopmentofhypertension . |
| |
| Keywords: | Hypertension Heat shockproteins 70 Antibodies Logisticmodels |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
|
