Non-interaction of ketotifen and theophylline in children with asthma – an acute study |
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| Authors: | M. Garty D. Scolnik Y. Danziger B. Volovitz D. N. Ilfeld I. Varsano |
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| Affiliation: | (1) Clinical Pharmacology Unit, Department of Medicine C, Beilinson Medical Center, Sackler School of Medicine, Tel-Aviv University, Petah Tikva, Israel;(2) Clinical Pharmacology Unit, Department of Paediatrics B, Beilinson Medical Center, Sackler School of Medicine, Tel-Aviv University, Petah Tikva, Israel |
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| Abstract: | Summary Six asthmatic children participated in an acute crossover randomized study. They received a single dose of aminophylline syrup 6 mg/kg after having received ketotifen syrup 1 mg b.i.d. or place-bo for 8 days. Ketotifen did not significantly affect the heart rate, pulse pressure or such pharmacokinetic parameters of theophylline as peak serum level, time to peak, half life and AUC. Thus, ketotifen had no significant effect on the disposition of theophylline. |
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| Keywords: | ketotifen asthma theophylline disposition drug interaction children |
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