| 纳米羟基磷灰石修复牙槽骨缺损的动物实验研究 |
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| 引用本文： | 孙庆顺,孟祥才,梁楠.纳米羟基磷灰石修复牙槽骨缺损的动物实验研究[J].黑龙江医药科学,2003,26(3):6-7. |
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| 作者姓名： | 孙庆顺 孟祥才 梁楠 |
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| 作者单位： | 1. 佳木斯大学口腔医学院,黑龙江,佳木斯,154002
2. 佳木斯大学,黑龙江,佳木斯,154002 |
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| 摘 要： | 目的：探讨纳米羟基磷灰石(Nano—HA)的生物学性质和在牙槽骨缺损修复中的成骨机制，为进一步的动物和临床实验提供理论依据。方法：在兔牙槽骨颊侧骨板做人为骨开窗，实验组填入纳米羟基磷灰石，空白对照组不做充填，羟基磷灰石对照组充填普通羟基磷灰石(HA)。于4周、8周、12周分别处死动物做组织学切片。结果：实验组无异物排斥反应，Nano—HA参与骨形成最终被降解。骨修复显著，大量新骨形成，与空白对照组的骨修复比较快速而且活跃。结论：Nano—HA具有良好的生物相容性、生物降解性、骨引导性，能加速牙槽骨的修复，为应用Nano—HA修复牙周病引起的牙槽骨缺损提供了理论依据。
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| 关 键 词： | 纳米羟基磷灰石 牙槽骨 骨缺损 |
| 文章编号： | 1008-0104(2003)03-0006-02 |
| 修稿时间： | 2003年3月17日 |
Animal experimental study on alveolar bone defect with Nano-hydroxyapatite |
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| SUN Qing-shun ,MENG Xiang-cai ,LIANG Nan.Animal experimental study on alveolar bone defect with Nano-hydroxyapatite[J].Heilongjiang Medicine and Pharmacy,2003,26(3):6-7. |
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| Authors: | SUN Qing-shun MENG Xiang-cai LIANG Nan |
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| Institution: | SUN Qing-shun 1,MENG Xiang-cai 2,LIANG Nan 1 |
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| Abstract: | Objective: To observe the reconstruction of alveolar bone defect by using Nano-hydroxyapatite(Nano-HA) and to provide theoretical basis for further animal and clinical study. Methods: Nano-HA was implanted in man-made alveolar bone defect in experimental group, with nonimplanted or implanted hydroxyapatite(HA) as control group .Make observation was made by using histological study at 4,8,12 weeks. Results: Histological study showed Nano-HA participated in new bone formation, was hardly rejected by hosts and was degraded at last. with new more bone formation in experiment group than in control group. Conclusions: Nano-HA has better biocompatibility, biodegradation and osteoconductivity.It may accelerate alveolar bone reconstruction. |
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| Keywords: | Nano-hydroxyapatite alveolar bone bone defect |
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