| 康莱特注射液与泰素帝合用对肺癌细胞的增敏作用研究 |
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| 引用本文： | 李瑛,焦顺昌,孙胜杰,魏秀芳. 康莱特注射液与泰素帝合用对肺癌细胞的增敏作用研究[J]. 中药新药与临床药理, 2005, 16(6): 424-426 |
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| 作者姓名： | 李瑛 焦顺昌 孙胜杰 魏秀芳 |
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| 作者单位： | 解放军总医院肿瘤科,北京,100853 |
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| 摘 要： | 目的研究康莱特注射液与泰素帝合用对人肺腺癌细胞95D的抑制作用,并寻找康莱特在联合化疗时的最佳给药时机.方法以体外人肺腺癌95 D细胞为研究对象,采用四甲基偶氮唑盐(MTT)比色法研究康莱特对泰素帝的化疗增敏作用.结果康莱特单药对人肺腺癌95 D细胞的生长有抑制作用,联合泰素帝的抑制率高于单药组;康莱特先于泰素帝18 h加入对95D的抑制作用最强.结论康莱特对体外肺癌细胞有抗肿瘤和化疗增敏作用;康莱特先于泰素帝18 h加入对95D的抑制作用最强.为康莱特的临床应用提供合理用药的方法.
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| 关 键 词： | 康莱特注射液 人肺腺癌细胞株95D 化疗增敏 |
| 文章编号： | 1003-9783（2005）06-0424-03 |
| 收稿时间： | 2005-07-13 |
| 修稿时间： | 2005-07-13 |
Research on the Effect of Kanglaite Injection on Enchancing Lung Cancer Cell''''s Sensitivity to TXT Injection |
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| LI Ying,JIAO Shunchang,SUN Shenjie,WEI Xiufang. Research on the Effect of Kanglaite Injection on Enchancing Lung Cancer Cell''''s Sensitivity to TXT Injection[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2005, 16(6): 424-426 |
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| Authors: | LI Ying JIAO Shunchang SUN Shenjie WEI Xiufang |
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| Affiliation: | Departmet of oncology, PLA General Hospital, Beijing 100853 |
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| Abstract: | Objective To investigte the inhibit effects of drug combination of Kanglaite injection(KLT) and TXT on human pulmonary epithelial cells(95D) in vitro,and to find the best time of combination.Method 95D cell growth inhibition was measured with MTT assay.Results Various concentration of KLT and TXT could inhibit the proliferation of 95D cell,and KLT could enchance the sensiti vity of 95D cell to TXT(P<0.005),especially when KLT was used before TXT for 18 hours.Conclusion KLT could sensitize 95D cell to TXT in vitro. |
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| Keywords: | Kanglaite injection 95D cell Chemosensitization |
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