Bile duct carcinoma following abdominal radiation for urologic neoplasms |
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Authors: | G Froeschle U Meyer-Pannwitt R Schwarz C Werner and B Kremer |
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Institution: | (1) Department of Surgery, Hamburg University School of Medicine, Martinistr. 52, 20246 Hamburg, Germany;(2) Department of Radiation Therapy, Hamburg University School of Medicine, Martinistr. 52, 20246 Hamburg, Germany;(3) Department of Anesthesiology, Hamburg University School of Medicine, Martinistr. 52, 20246 Hamburg, Germany |
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Abstract: | This report concerns three cases of bile duct carcinoma which occurred 15–40 years after patients received treatment for urogenital
neoplasia. All three patients had initially received radiation therapy in addition to urological surgery. Jaundice was the
major clinical symptom of the second tumor. Two of the three patients were able to be surgically treated when presenting with
their second carcinoma (partial pancreaticoduodenectomy, bile duct resection; central liver resection), whereas the third
patient was in such a poor state of health that he was biopsied only and treated with a pigtail drain. All three patients
died within 3 months to 3 years following the diagnosis of the second tumor. The more than coincidential occurrence of the
rare bile duct carcinoma in our three patients with previous urogenital neoplasia warrants a new discussion concerning the
connection between primary carcinoma, radiation therapy, and the occurrence of a second tumor. |
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Keywords: | bile duct carcinoma urogenital neoplasia radiation therapy induced malignancies |
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