细胞感知重力变化(可能)的分子机制

虽然我们早已知道重力改变可以导致细胞结构和功能的广泛变化,但是,对于单细胞如何感知这些力学信号,又如何将它们转化成生物信号的过程了解甚少.新近研究普遍支持重力变化对细胞的影响分直接作用和间接作用两种,而且在实际的太空飞行中两种作用机制交缠,一起影响着单个细胞的结构和功能.有关重力变化如何导致细胞改变的机制,目前尚不完全清楚,但大量研究对此进行了比较深入的探索,大致可以分为以下几个途径:(1)预应力感知途径;(2)细胞骨架感知途径;(3)应力感知离子通道途径;(4)理化性质改变的间接影响途径.

(Possible) Molecular Mechanism of Cells in Gravisensing

Although it is clear that changes of gravity can alter dramatically the functions and structures of cells,little is known about how living cells sense these signals and convert them into a biochemical response.Recent studies estimated that the changes of gravity might influence the single cell directly and indirectly.So far,the molecular mechanism of gravisensing remains unknown,however,according to a great deal of researches focusing on this point,several pathways could be considered:(1) Pre-stress perception pathway;(2) Cytoskeleton-perception pathway;(3) Stress-sensitive ion channel pathway;(4) Indirect effects of gravitational change.