长期服用青木香或冠心苏合丸对大鼠肝、肾功能的影响

目的:评价青木香的毒性,为临床合理用药提供实验依据。方法:长期给予不同组大鼠2.5 g.kg^-1的青木香、2.5 g.kg^-1的冠心苏合丸(含青木香)和2.5 g.kg^-1的冠心苏合丸(不含青木香),检测各组大鼠的凝血酶原时间(PT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、碱性磷酸酶(ALP)、肌酐(Crea)和尿素氮(BUN)等指标,并对肾脏、肝脏、胃和膀胱进行病理学检查。结果:青木香和冠心苏合丸(含青木香)组PT,ALT,AST,ALB,ALP,Crea和BUN等指标均发生显著性改变,病理检查发现肝、肾均有坏死现象,胃和膀胱均发生癌变。结论:青木香和冠心苏合丸(含青木香)具有强烈的毒性,均能损害大鼠的肾脏和肝脏,并引起胃和膀胱的肿瘤。

Hepatic and renal injury induced by Radix Aristolochiae or Guanxin Suhe Wan for a long term in rats

Objective: To evaluate the toxicity of Radix Aristolochiae supplied experimental evidence of rational use of drug in clinic. Method: After treatment with small dose Radix Aristolochiae,Guanxin Suhe Wan(with Radix Aristolochiae) and Guanxin Suhe Wan(without Radix Aristolochiae) in different group for a long term,respectively,the biochemical indicator of PT,ALT,AST,ALB,ALP,Crea and BUN were detected,and the kidney,liver,stomach and urinary bladder were examined by pathologic assaying. Result: In Radix Aristolochiae group and Guanxin Suhe Wan(with Radix Aristolochiae) group,all of biochemical indicator were changed significantly,and hepatonecrosis,renal tubular necrosis,gastric carcinoma and bladder carcinoma were discovered.Conclusion: Radix Aristolochiae and Guanxin Suhe Wan(with Radix Aristolochiae) can damage kidney and liver,and cause gastric carcinoma and bladder carcinoma by intensive toxicity.