应用视网膜电图评估早产儿视网膜病变退化后的视功能

目的通过闪光视网膜电图（flash electroretinogram,F-ERG）评估曾患早产儿视网膜病变（retinopathy ofprematurity,ROP）但自行消退的患儿的视功能情况,比较其与正常早产儿的异同。方法随机选择胎龄为26~36周,出生体重为990-2700g,曾患早产儿视网膜病变但自行消退的早产儿15例（30只眼）在半岁~2岁进行F-ERG检查,并选择胎龄、出生体重和检查年龄相似的正常早产儿作为对照组,对比F-ERG各波的振幅和潜伏期。结果 ROP组和正常对照组视杆反应b波潜伏期的差异有统计学意义（P〈0.05）,最大混合反应a波、b波,视锥反应a波、b波潜伏期的差异均无统计学意义;视杆反应b波,最大混合反应a波、b波,视锥反应a波、b波振幅及30Hz闪烁光及振荡电位峰值的差异均无统计学意义（P〉0.05）。结论早产儿视网膜病变退化后对患儿的视功能影响不大,因此,发现轻度的早产儿视网膜病变不必急于手术,可以密切观察其能否消退疾病进展再考虑是否手术,视杆细胞功能的损伤可考虑以后行视功能训练。

Research on retinal function of degraded ROP preterm newborns with flash electroretinogram

Objective To estimate the retinal function in degraded ROP preterm newborns with FERG.Methods Fifteen subjects(30 eyes) that had suffered from ROP but degradation and fifteen preterm newborns(30 eyes) with no sign of ROP were random selected.Gestational age at birth ranged from 26 to 36 weeks and birth weight from 990 to 2770 gramsin ROP group.Control subjects had similar gestational age and birth weight.All subjects were tested with flash electroretinogram at age range 6 to 24 months.Results Statistical an...