| 马来酸氟吡汀在汉族健康人体内的药动学研究 |
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| 引用本文： | 夏东亚,郭涛,刘龙兴,唐云彪,颜鸣.马来酸氟吡汀在汉族健康人体内的药动学研究[J].中国药学杂志,2011,46(3):218-220. |
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| 作者姓名： | 夏东亚 郭涛 刘龙兴 唐云彪 颜鸣 |
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| 作者单位： | 沈阳军区总医院药剂科;沈阳药科大学药学院; |
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| 基金项目： | 全军医学科学技术研究“十一五”计划科技攻关课题基金资助项目(06G023) |
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| 摘 要： | 目的 研究马来酸氟吡汀在中国汉族健康人体的药动学。方法 选择10名汉族健康受试，口服马来酸氟吡汀胶囊100 mg。用高效液相色谱法测定给药后不同时间点的马来酸氟吡汀的血浆浓度，用3P97程序估算药动学参数。结果 口服马来酸氟吡汀胶囊100 mg后，氟吡汀的药-时曲线符合一级吸收二室模型，主要药动学参数为： tmax（1.70±0.79h，ρmax（1 078.1±296.7μg·L-1，t1/2α（1.46±0.51h，t1/2β（9.37±2.57h，AUC0-∞（8 971.7±1 996.5μg·h·L-1。结论 健康受试者单剂量口服马来酸氟吡汀胶囊的药动学参数与文献报道基本一致。
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| 关 键 词： | 马来酸氟吡汀 药动学 高效液相色谱法 血药浓度 |
| 收稿时间： | 2011-11-11; |
Pharmacokinetics of Flupirtine maleate in Chinese Han Nationality Healthy Volunteers |
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| XIA Dong-ya,GUO Tao,LIU Long-xing ,TANG Yun-biao,YAN Ming.Pharmacokinetics of Flupirtine maleate in Chinese Han Nationality Healthy Volunteers[J].Chinese Pharmaceutical Journal,2011,46(3):218-220. |
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| Authors: | XIA Dong-ya GUO Tao LIU Long-xing TANG Yun-biao YAN Ming |
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| Institution: | XIA Dong-ya1,GUO Tao1,LIU Long-xing 1,2,TANG Yun-biao1,YAN Ming1(1.Department of Pharmacy,General Hospital of Shenyang Military Region,Shenyang 110840,China,2.Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | OBJECTIVE To investigate the pharmacokinetics of flupirtine maleate in Chinese Han nationality healthy volunteers.METHODS10 Healthy volunteers were given with a single oral dose(100 mg) of flupirtine maleate capsule.Blood samples were collected from vein at certain sampling times.Flupirtine maleate in plasma were determined by HPLC fluorescence method,and the pharmacokinetic parameters were calculated by 3P97 software.RESULTSThe plasma concentration-time curves of flupirtine were discribed by a two-compartm... |
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| Keywords: | flupirtine maleate pharmacokinetics HPLC plasma concentration |
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