原发性肝癌患者手术前后血浆可溶性P-选择素的检测及意义

目的：探讨原发性肝癌患者手术前后血浆可溶性P－选择素（sP-selectin)水平的变化及意义。方法：应用ELISA法检测39例原发性肝癌患者手术前后血浆sP-selectin的水平，结果：原发性肝癌患者术前的血浆sP-selectin含量明显高于正常对照组（P＜0．01），术后第15d，患者血浆sP-selectin含量较术前明显降低（P＜0．01），但仍明显高于正常对照组（P＜0．01），术后第30天，患者浆sP-selectin含量较术后牝15d进一步降低（P＜0．01），与正常对照组比较差异无显著性（P＞0．05），结论：提示原发性肝癌者血浆sP-selectin水平明显高于正常人，手术切除肝癌可降低患者血浆sP-selectin的水平，血浆sP-selectin水平的检测及动态观察可能对原发性肝癌的辅助诊断，病情的发展的判断，疗效观察以及预后估计会具有较大的临床意义。

SIGNIFICANCE OF DETECTING PLASMA SOLUBLE P-SELECTIN IN PATIENTS WITH PRIMARY LIVER CANCER BEFORE AND AFTER OPERATION

Objective To investigate the alteration and significance of plasma soluble P selectin (sP selectin) on patients with primary liver cancer(PLC)before and after operation.Methods The levels of plasma sP selectin in 39 patients with PLC were detected by ELISA method before and after operation.Results The content of plasma sP selectin of the patients with PLC were higher than those of normal control group(P<0.01).Fifteen days after operation,the content of plasma sP selectin of the patients were lower than those before operation (P<0.01),but still higher than those of normal control group (P<0.01).Thirty days after operation,the content of plasma sP selectin of the patients were further lower than those of 15th days after operation (P<0.01),but were not significantly different from those of normal control group (P>0.05).Conclusion The results indicats that the plasma sP selectin level is higher in patients with PLC than those of normal control group.The level of plasma sP selectin of the patient may decrease when the liver cancer is removed.Detecting the plasma sP selectin may be of value in making diagnosis,evaluating evolution of disease,observing curative effect as well as estimating prognosis for the patients with PLC.