Some effects of progestogens, oestrogens and androgens on the ocular tension of rabbits and owl monkeys.

Topically applied progestogens; progesterone, quingestanol acetate and norethisterone acetate, were shown to reduce the ocular tension of conscious rabbits. Quingestanol acetate and norethisterone acetate also reduced the ocular tension of conscious owl monkeys. It was found that quingestanol acetate did not increase outflow facility in anaesthetized rabbits, but it significantly reduced the clearance of [¹⁴C]inulin from the anterior chamber suggesting a reduction in aqueous flow. Androgens and oestrogens were not found to exert hypotensive effects in either species.