Vincristine induced cranial polyneuropathy |
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Authors: | Ali Bay Cahide Yilmaz Nebi Yilmaz Ahmet Faik Oner |
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Institution: | (1) Division of Hematology, Yuzuncu Yil University Faculty of Medicine, 65200 Van, Turkey;(2) Division of neurology, Yuzuncu Yil University Faculty of Medicine, 65200 Van, Turkey;(3) Division of neurosurgery, Yuzuncu Yil University Faculty of Medicine, 65200 Van, Turkey;(4) Yüzüncü Yyl University Faculty of Medicine, 65200 Van, Turkey |
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Abstract: | We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine
treatment. A 5-year-old girl was diagnosed preB cell Acute Lymphoblastic Leukemia (ALL). She received chemotherapy according
to the previously described modified St. Jude total therapy studies XIII. Five days after the fourth dose of vincristine,
she presented with bilateral ptosis. Neurological examination revealed bilateral ptosis, and complete external opthalmoplegia
with normal pupillary and corneal reflexes. She received 3.8 mg cumulative dose of vincristin before development of ptosis.
A neuroprotective and neuroregenerative treatment attempt with pyridoxine and pyridostigmine was initiated. The bilateral
ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks.
The both agents were given for 3 weeks and were well tolerated without any side effects. During the follow up period we did
not observe residue or recurrence of the ptosis. |
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Keywords: | Vincristine Ptosis Treatment |
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