吲哚胺2,3-双加氧酶在移植免疫中的作用研究进展

目的总结吲哚胺2，3-双加氧酶（indoleamine2，3-dioxygenase，IDO）参与免疫调节的可能机制，以及在移植免疫过程中的作用。方法广泛查阅近年国内外相关文献，对IDO分布、免疫调节机制及其在移植免疫中的作用研究进展进行回顾总结与分析。结果IDO通过降解局部组织微环境中的色氨酸、抑制宿主同种异体T细胞增殖而发挥免疫调节作用。应用转基因技术将IDO基因整合至目的细胞基因中并表达IDO，体内试验表明可明显延长异体移植物的平均存活时间。结论IDO在移植免疫中有广阔的应用前景，为提高异体移植物术后长期存活率提供了新的思路。

EFFECT OF INDOLEAMINE 2,3-DIOXYGENASE ON TRANSPLANTATION IMMUNITY

OBJECTIVE: To review the research progress of possible mechanism of indoleamine 2, 3-dioxygenase (IDO) in immunological regulation and function of transplantation immunity. METHODS: The advances in the IDO location, immunological regulatory mechanism and function of transplantation immunity were introduced based on the recent related literature. RESULTS: IDO played an immunoregulatory role by locally depleting tryptophan in tissue microenvironment which resulted in immunosuppression of allogeneic T-cell proliferation. IDO cDNA was delivered to chromosome in interesting cells by gene transfection and stimulated to express, which was associated with a prolongation in allograft survival in vivo. CONCLUSION: IDO offers a new way in transplantation immunity, and this provid novel method for elevating allograft survival rate.