脂蛋白脂酶活化剂NO-1886抑制糖尿病兔动脉粥样硬化的形成

目的　合成化合物NO 1886 ,一种脂蛋白脂酶活化观察脂蛋白脂酶活化剂是否降低高脂 /高蔗糖饲料诱发的糖尿病新西兰兔的血浆葡萄糖并减轻其动脉粥样硬化。方法　给予高脂 /高蔗糖饲料升高新西兰兔血浆总胆固醇 ,甘油三酯和葡萄糖及降低高密度脂蛋白胆固醇而导致动脉粥样硬化。饲料中加入 1 0 %NO 1886进行治疗观察。分别在 0、4、8、12、16、2 0及 2 4wk从禁食过夜的兔耳静脉抽取血样测定葡萄糖和脂质水平。第 2 4周末 ,处死动物 ,分离主动脉 ,经苏丹Ⅳ染色固定脂质后 ,计算脂纹病变面积。结果　应用NO 1886后 ,实验动物血浆葡萄糖 ,总胆固醇和甘油三酯降低 ,高密度脂蛋白胆固醇增加。对动脉粥样硬化的发展具有抑制作用。结论　NO 1886不仅可改善脂质紊乱 ,而且可降低血浆葡萄糖 ,减轻糖尿病兔动脉粥样硬化

Lipoprotein lipase activator NO-1886 suppresses atherosclerosis in aorta ofdiabetic rabbits

AIM To ascertain whether NO 1886 lowers plasma glucose and suppresses atherosclerosis in high fat/high sucrose induced diabetic New Zealand white rabbits. METHODS 1 0% NO 1886 was supplemented into the high fat/high sucrose feed for treating the rabbits for 20 weeks. Blood samples for glucose and lipid measurements were withdrawn from auricular veins at weeks 0, 4, 8, 12, 16, 20 and 24 after fasting overnight. The fatty streak lesions of the aortas were quantified following lipid staining with Sudan Ⅳ. RESULTS NO 1886 resulted in decreased plasma glucose, total cholesterol and triglyceride levels and increased HDL C levels. Furthermore, NO 1886 provided protection against the development of atherosclerosis in the aorta. CONCLUSION NO 1886 not only ameliorates the lipid disorder, but also lowers plasma glucose level, and suppresses atherosclerosis in the aorta of diabetic rabbits.