| 散打运动员β2肾上腺素能受体基因多态性研究 |
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| 引用本文： | Chen L,Sun C,Deng L. 散打运动员β2肾上腺素能受体基因多态性研究[J]. 生物医学工程学杂志, 2012, 29(1): 129-133 |
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| 作者姓名： | Chen L Sun C Deng L |
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| 作者单位： | 重庆大学生物工程学院;成都体育学院武术系 |
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| 基金项目： | 重庆市自然科学基金计划重点项目资助(CSTC,2010BA5001);重庆大学大型仪器设备开发基金资助项目(2010063057) |
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| 摘 要： | 观察β2肾上腺素能受体(β2-AR)Arg16Gly的基因型和等位基因频率在我国散打运动员中的分布,探讨散打运动员与普通汉族人群关于该位点多态性的差异。应用等位基因特异性引物PCR技术,检测61名散打运动员和50名普通汉族人β2-AR Arg16Gly基因多态性。结果显示,AA基因型,A等位基因和G等位基因在散打运动员组与普通汉族人组之间的差异具有显著性(2=6.646,P=0.01,P<0.05;2=4.003,P=0.045,P<0.05;2=4.003,P=0.045,P<0.05),普通汉族人的AA基因型频率和A等位基因频率明显高于散打运动员的AA基因型频率和A等位基因频率。
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| 关 键 词： | 散打 β2肾上腺素能受体 基因多态性 |
The study of beta2-adrenergic receptor gene polymorphism in Sanda athletes |
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| Chen Ling,Sun Chao,Deng Linhong. The study of beta2-adrenergic receptor gene polymorphism in Sanda athletes[J]. Journal of biomedical engineering, 2012, 29(1): 129-133 |
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| Authors: | Chen Ling Sun Chao Deng Linhong |
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| Affiliation: | Bioengineering College, Chongqing University, Chongqing 400044, China. |
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| Abstract: | This study observed the disposition of beta2-adrenergic receptor (beta2-AR) Arg16Gly genotype and allele frequency among Sanda athletes in China, and investigated the diversity about the single nucleotide polymorphism of beta2-AR Arg16Gly between Sanda athletes and normal people of Han nationality in China. We used the technique of allele specified primer polymerase chain reaction to detect ADRB2 gene polymorphism of Sanda athletes (61 subjects) and normal Han nation people (50 subjects). The results showed there were significant differences about AA genotype, A allele, and G allele between Sanda athletes group and normal Han nation group (AA: chi2 = 6.646, P = 0.01, P < 0.05; A: chi2 = 4.003, P = 0.045, P < 0.05; G: chi2 = 4.003, P = 0.045, P < 0.05), and the frequency of AA genotype and A allele in the group of normal Han nation was higher than that in the group of Sanda athletes. |
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| Keywords: | Sanda β2-adrenergic receptor(β2-AR) Gene p olymorphism |
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