| 精原干细胞自我更新与分化的调控 |
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| 引用本文： | 李冬梅,秦晓东. 精原干细胞自我更新与分化的调控[J]. 中华男科学杂志, 2013, 0(11): 963-967 |
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| 作者姓名： | 李冬梅 秦晓东 |
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| 作者单位： | 南京大学医学院免疫与生殖生物学实验室,江苏南京210093 |
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| 基金项目： | 国家自然科学基金（21377052）;江苏省自然科学基金（BK20131281） |
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| 摘 要： | 精原干细胞(SSCs)是精子发生过程的起源,有独特的复制方式:一次分裂可形成两个分化细胞,也可形成一个分化细胞和一个干细胞,这种自我更新和分化受到严密的调控,包括微环境、胶质细胞源性神经营养因子(GDNF)、多种信号通路等。本文综述SSCs的自我更新与分化及其调节机制,对于深入了解精子发生及男性精子发生障碍性不育、探讨睾丸肿瘤发生和寻找新的潜在治疗靶点等诸多方面有理论意义。
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| 关 键 词： | 精原干细胞 自我更新 分化 |
Regulation of the self.renewal and differentiation of spermatogonial stem cells |
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| LI Dong-mei,QIN Xiao-dong. Regulation of the self.renewal and differentiation of spermatogonial stem cells[J]. National journal of andrology, 2013, 0(11): 963-967 |
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| Authors: | LI Dong-mei QIN Xiao-dong |
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| Affiliation: | Laboratory of Immunology and Reproductive Biology, Nanjing University School of Medicine, Nanfing, Jiangsu 210093, China |
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| Abstract: | [ Abstract] Spermatogonial stem cells （SSCs） play an important role in spermatogenesis and have a unique mode of replication. A single SSC can produce two differentiating cells, or one stem cell and one differentiating cell. The self-renewal and differentiation of SSCs are precisely regulated as relating the niche of SSCs, glial cell line-derived neurotrophic factor, and several signaling pathways. This article reviews the self-renewal and differentiation of SSCs and their regulation mechanisms, which may offer a deeper insight into spermatogenesis and male infertility and pave a theoretical ground for studying testicular tumorigenesis and searching for new potential approaches to the treatment of testicular cancer and other related diseases. Natl J Androl, 2013, 19 （11） ： 963 -967 |
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| Keywords: | spermatogonial stem cell self-renewal differentiation |
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