疏肝益阳胶囊联合西药治疗Ⅲ型前列腺炎合并勃起功能障碍的临床疗效

目的:探讨疏肝益阳胶囊联合常规西药方案(盐酸坦洛新缓释片+普适泰片)治疗Ⅲ型前列腺炎合并勃起功能障碍(ED)的临床疗效。方法:80例确诊为Ⅲ型前列腺炎合并ED的患者,随机分为试验组和对照组,每组各40例。试验组患者采用疏肝益阳胶囊联合盐酸坦洛新缓释片和普适泰片进行治疗,对照组患者仅用盐酸坦洛新缓释片和普适泰片进行治疗,治疗时间均为8周。采用NIH-CPSI评价患者的前列腺炎症状,采用国际勃起功能指数-5(IIEF-5)评价患者的勃起功能情况,采用综合性医院焦虑抑郁量表(HADA和HADD)评价患者的精神心理状态。分别统计两组的治愈人数、显效人数、有效人数和无效人数,并计算治愈率、显效率、有效率和无效率。结果:两组患者治疗4周与治疗前相比,治疗8周与治疗前相比,治疗8周与治疗4周相比,NIH-CPSI、IIEF-5、HADA和HADD等指标差异均有明显统计学意义(P<0.01)。治疗8周后,试验组NIH-CPSI、IIEF-5、HADA和HADD指标值分别为6.83±4.96、21.03±2.54、6.05±1.62、5.35±3.30;对照组4项指标值分别为7.55±4.89、17.68±4.15、6.88±2.45、7.85±3.77,试验组与对照组相比各项指标改善具有统计学差异(P<0.05)。试验组治疗的有效率为90%(36/40),对照组治疗的有效率为70%(28/40),差异有统计学意义(P<0.05)。结论:疏肝益阳胶囊联合α-受体阻滞剂、植物制剂等常规药物可以有效治疗慢性前列腺炎患者伴发ED,改善精神心理问题,提高慢性前列腺炎治疗的有效率。

Clinical efficacy of Shuganyiyang Capsule combined with Western medicine for the treatment of type III prostatitis complicated by erectile dysfunction

[ Abstract] Objective： To investigate the clinical efficacy of Shuganyiyang Capsule combined with conventional Western medi- cine （tamsulosin hydrochloride sustained release tablets ＋ prostat tablets） for the treatment of type m prostatitis complicated by erec- tile dysfunction （ED）. Methods： Eighty patients with type III prostatitis complicated by ED were equally randomized to an experi- mental and a control group, the folaner treated with Shuganyiyang Capsule combined with tamsulosin hydrochloride sustained release tablets and prostat tablets, while the latter with tamsulosin hydrochloride and prostat only, both for 8 weeks. Then the prostatitis symp- toms, erectile function and psychological conditions of the patients were evaluated using NIH-CPSI, IIEF-5, and hospital anxiety and depression scale （HADA and HADD） respectively. The rates of recovery, excellence, effectiveness and ineffectiveness were calculated. Results： The scores on NIH-CPSI, IIEF-5, HADA and HADD obtained at 4 and 8 weeks after treatment showed statistically sig- nificant differences between the two time points as well as from the baseline （P 〈0.01 ）. At 8 weeks, the scores on NIH-CPSI, IIEF- 5, HADA and HADD were 6.83 ±4.96, 21.03 ±2.54, 6.05 ±1.62, and 5.35 ±3.30 in the experimental group, as compared with 7.55 ±4.89, 17.68 ±4.15, 6.88 ±2.45, and 7.85 ±3.77 in the control （P 〈 0.05）. The rate of effectiveness was significantly higher in the experimental than in the control group （ 90% [ 36/40 ] vs 70% [ 28/40 ], P 〈0O. 05 ）. Conclusion ： Shuganyiyang Capsule combined with conventional Western medicine, such as alpha blockers and galenica, produces definite effect on chronic prosta- titis complicated by ED, improves the psychological conditions of the patient, and enhances the therapeutic efficiency of chronic prosta- titis. Natl J Androl, 2013, 19 （11） ： 1034 -1038