| 白细胞介素—1受体拮抗剂对角膜碱烧伤治疗的实验研究 |
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| 引用本文： | 任华,单清,张杰,王登龙,姜严明,钱焕文. 白细胞介素—1受体拮抗剂对角膜碱烧伤治疗的实验研究[J]. 眼科研究, 2001, 19(5): 392-395 |
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| 作者姓名： | 任华 单清 张杰 王登龙 姜严明 钱焕文 |
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| 作者单位： | 军事医学科学院放射医学研究所北京100850 |
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| 摘 要： | 目的 系统观察研究白细胞介素-1受体拮抗剂（LI-lra)对角膜碱烧伤的治疗作用。方法 采用日本大耳白兔及Wistar大鼠，制成角膜碱烧伤模型。通过裂隙灯与病理组织学观察，进行角膜OD值与角膜上皮细胞活性测定。烧伤斑图像分析。以及IL-1酶联免疫吸附测定（IL-1ELISA）。结果 应用IL-1ra后兔角膜水肿程度减轻，角膜OD值较大，角膜上皮细胞活性恢复较好，并能明显抑制大鼠角膜中的IL-1水平。结论 IL-1ra能抑制炎症反应。有利于角膜透明度和上皮细胞活性恢复。
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| 关 键 词： | 白细胞介素－1受体拮抗剂 角膜碱烧伤 LI－lra 治疗 |
| 修稿时间： | 2000-10-18 |
Study of the therapeutical effect of IL-1ra on corneal alkali burn |
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| Ren Hua,Shan Qing,Zhang Jie,et al.. Study of the therapeutical effect of IL-1ra on corneal alkali burn[J]. Chinese Ophthalmic Research, 2001, 19(5): 392-395 |
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| Authors: | Ren Hua Shan Qing Zhang Jie et al. |
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| Affiliation: | Ren Hua,Shan Qing,Zhang Jie,et al. Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850 |
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| Abstract: | Objective To study the treatment of animal cornea alkali burn by Interleukin-1 receptor antagonist(IL-1ra). Methods Cornea of rabbits and rats were burned by alkali. Six items including the observation of slit-lamp and pathology,deter- mination OD value of cornea and activity of corneal epithelial cell,cornea burn image analysis and IL-1 ELISA were used to exam- ine the therapeutic effect of IL-1ra. Results IL-1ra can control inflammation and is beneficial to recovery of rabbits corneal transparency and epithelial cell activity. IL-1ra can also inhibit IL-1 level of rats. Conclusion IL-1ra was therapeutic in corne- al alkali burn. |
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| Keywords: | Interleukin-1 receptor antagonist cornea alkali burn |
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